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dc.contributor.authorSantos Durán, Gabriel Nicolás
dc.contributor.authorFerreiro Galve, Susana
dc.contributor.authorMenuet, Arnaud
dc.contributor.authorQuintana Urzainqui, Idoia
dc.contributor.authorMazan, Sylvie
dc.contributor.authorRodríguez-Moldes Rey, María Isabel
dc.contributor.authorCandal Suárez, Eva María
dc.date.accessioned2017-10-21T13:11:39Z
dc.date.available2017-10-21T13:11:39Z
dc.date.issued2016-11-24
dc.identifier.citationSantos-Durán GN, Ferreiro-Galve S, Menuet A, Quintana-Urzainqui I, Mazan S, Rodríguez-Moldes I and Candal E (2016) The Shark Alar Hypothalamus: Molecular Characterization of Prosomeric Subdivisions and Evolutionary Trends. Front. Neuroanat. 10:113. doi: 10.3389/fnana.2016.00113
dc.identifier.urihttp://hdl.handle.net/10347/16010
dc.description.abstractThe hypothalamus is an important physiologic center of the vertebrate brain involved in the elaboration of individual and species survival responses. To better understand the ancestral organization of the alar hypothalamus we revisit previous data on ScOtp, ScDlx2/5, ScTbr1, ScNkx2.1 expression and Pax6 immunoreactivity jointly with new data on ScNeurog2, ScLhx9, ScLhx5, and ScNkx2.8 expression, in addition to immunoreactivity to serotonin (5-HT) and doublecortin (DCX) in the catshark Scyliorhinus canicula, a key species for this purpose since cartilaginous fishes are basal representatives of gnathostomes (jawed vertebrates). Our study revealed a complex genoarchitecture for the chondrichthyan alar hypothalamus. We identified terminal (rostral) and peduncular (caudal) subdivisions in the prosomeric paraventricular and subparaventricular areas (TPa/PPa and TSPa/PSPa, respectively) evidenced by the expression pattern of developmental genes like ScLhx5 (TPa) and immunoreactivity against Pax6 (PSPa) and 5-HT (PPa and PSPa). Dorso-ventral subdivisions were only evidenced in the SPa (SPaD, SPaV; respectively) by means of Pax6 and ScNkx2.8 (respectively). Interestingly, ScNkx2.8 expression overlaps over the alar-basal boundary, as Nkx2.2 does in other vertebrates. Our results reveal evidences for the existence of different groups of tangentially migrated cells expressing ScOtp, Pax6, and ScDlx2. The genoarchitectonic comparative analysis suggests alternative interpretations of the rostral-most alar plate in prosomeric terms and reveals a conserved molecular background for the vertebrate alar hypothalamus likely acquired before/during the agnathan-gnathostome transition, on which Otp, Pax6, Lhx5, and Neurog2 are expressed in the Pa while Dlx and Nkx2.2/Nkx2.8 are expressed in the SPa
dc.description.sponsorshipThis work was supported by grants from the Spanish Dirección General de Investigación-FEDER (BFU2010-15816, BFU2014-58631-P), the Xunta de Galicia (10PXIB200051PR, IN 845B-2010/159, CN 2012/237), the Région Centre, Région Bretagne (EVOVERT grant number 049755; PEPTISAN project), National Research Agency (grant ANR-09-BLAN-026201), CNRS, Universitéd’Orléans and Université Pierre et Marie Curie
dc.language.isoeng
dc.publisherFrontiers Media
dc.relationinfo:eu-repo/grantAgreement/MICINN/Plan Nacional de I+D+i 2008-2011/BFU2010-15816/ES/BUSCANDO LA CONDICION ANCESTRAL DE LA ORGANIZACION CEREBRAL DE GNATOSTOMOS: REGIONALIZACION, MIGRACION, PROYECCIONES Y ASIMETRIAS EN EL CEREBRO EN DESARROLLO DE UN TIBURON
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2014-58631-P/ES/ESTUDIO DE LA NEUROGENESIS EN CEREBRO EMBRIONARIO Y ADULTO DESDE UNA PERSPECTIVA EVOLUTIVA
dc.rights© 2016 Santos-Durán, Ferreiro-Galve, Menuet, Quintana-Urzainqui, Mazan, Rodríguez-Moldes and Candal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
dc.subjectChondrichthyan
dc.subjectForebrain
dc.subjectAlar/basal boundary
dc.subjectEvolution
dc.subjectDevelopment
dc.subjectPax6
dc.subjectOtp
dc.subjectDlx
dc.titleThe Shark Alar Hypothalamus: Molecular Characterization of Prosomeric Subdivisions and Evolutionary Trends
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3389/fnana.2016.00113
dc.relation.publisherversionhttps://doi.org/10.3389/fnana.2016.00113
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1662-5129
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Bioloxía Funcional
dc.description.peerreviewedSI


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