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dc.contributor.authorFernández Rosas, Josefa
dc.contributor.authorPessego, Marcia
dc.contributor.authorAcuña, Angel
dc.contributor.authorVazquez-Vazquez, Carlos
dc.contributor.authorMontenegro, Javier
dc.contributor.authorParajo, Mercedes
dc.contributor.authorRodriguez-Dafonte, Pedro
dc.contributor.authorNome, Faruk
dc.contributor.authorGarcía-Río, Luis
dc.identifier.citationFernández-Rosas, J., Pessego, M., Acuña, A., Vazquez-Vazquez, C., Montenegro, J., & Parajo, M. et al. (2018). Novel Supramolecular Nanoparticles Derived From Cucurbit[7]uril and Zwitterionic Surfactants. Langmuir.
dc.description.abstractBinding constants, Log K ≈ 6.6 M-1, and NMR characterization of the complexes formed by sulfobetaines and cucurbit[7]uril (CB7) support the electrostatic interaction as major driving force. This very strong binding motif is cross-linked by additional CB7 molecules resulting in the formation of supramolecular nanoparticles (SNPs) with an average diameter of 172 nm and negative surface potential. The time course evolution of the particle size and the surface potential suggests the very fast formation of an amorphous aggregate that absorbs additional amount of sulfobetaine. These aggregates afford very stable (more than two weeks) nanoparticles in aqueous dispersion. The reversibility of the sulfobetaine/CB7 host:guest complexes allows SNPs disaggregation by adding a competitive guest as shown by treatment with tetraethylammonium chloride. The addition of this competitive cation triggers a SNPs to micelle transition. The potential application of these nanoparticles as drug delivery vehicles was investigated by using carboxyfluorescein. These experiments revealed that upon externally induced disruption of the SNPs (by tetraethylammonium chloride) the fluorescent dye was trapped into micellar aggregates that can be further disrupted by cyclodextrin addition
dc.description.sponsorshipFinancial support from Ministerio de Economia y Competitividad of Spain (projects CTQ2014-55208-P, CTQ2017-84354-P, CTQ2014-59646-R and MAT2015-67458-P), Xunta de Galicia (GR 2007/085; IN607C 2016/03 and Centro singular de investigación de Galicia accreditation 2016-2019, ED431G/09) and the European Union (European Regional Development Fund – ERDF), is gratefully acknowledged. J.M. received a Ramón y Cajal (RYC-2013- 13784) and a starting grant from the ERC (DYNAP677786)
dc.publisherAmerican Chemistry Society
dc.rights© 2018 American Chemical Society
dc.titleNovel Supramolecular Nanoparticles Derived From Cucurbit[7]uril and Zwitterionic Surfactants
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares

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