pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10347/16691
Files in this item
Metadata
Title: | pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets |
Author: | Méndez Ardoy, Alejandro Granja Guillán, Juan Ramón Montenegro García, Javier |
Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Date of Issue: | 2018-04-03 |
Publisher: | Royal Society of Chemistry |
Citation: | Méndez-Ardoy, A., Granja, J., & Montenegro, J. (2018). pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets. Nanoscale Horizons. http://dx.doi.org/10.1039/c8nh00009c |
Abstract: | The controlled one-dimensional supramolecular polymerization of synthetic building blocks in confined spaces constitutes a key challenge to simplify the understanding of the fundamental physical principles behind the behavior of more complex encapsulated polymer networks. Cyclic peptide nanotubes constitute an optimal scaffold for the fabrication of hierarchical one-dimensional self-assembled architectures. Herein we report the pH-controlled nanotube formation and fibrillation of supramolecular cyclic peptides in confined aqueous droplets. The externally triggered self-assembly of these peptides gave rise to viscoelastic hydrogels in which the one-dimensional molecular arrangement was perfectly preserved from the nano- to the micro-scale. The cyclic peptide building blocks were confined inside water microdroplets and the base-triggered supramolecular polymerization was externally triggered and followed by confocal microscopy showing that the confined fibrillation spanned and affected the shape of the droplet micro container |
Description: | This is the Accepted Manuscript of the following article: Méndez-Ardoy, A., Granja, J., & Montenegro, J. (2018). pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets. Nanoscale Horizons. http://dx.doi.org/10.1039/c8nh00009c |
Publisher version: | https://doi.org/10.1039/C8NH00009C |
URI: | http://hdl.handle.net/10347/16691 |
DOI: | 10.1039/C8NH00009C |
ISSN: | 2055-6756 |
E-ISSN: | 2055-6764 |
Rights: | © Royal Society of Chemistry 2018 |
Collections
-
- CIQUS-Artigos [436]
- QO-Artigos [391]