Anion recognition and induced self-assembly of an alpha,gamma-cyclic peptide to form spherical clusters
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Title: | Anion recognition and induced self-assembly of an alpha,gamma-cyclic peptide to form spherical clusters |
Author: | Rodríguez-Vázquez, Nuria Amorín López, Manuel Granja Guillán, Juan Ramón Alfonso, Ignacio |
Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Subject: | Anionrecognition | Cyclic peptide | Self-assembling | Supramolecular chemistry | Transport | |
Date of Issue: | 2016-03-21 |
Publisher: | Wiley |
Citation: | Rodríguez-Vázquez, N., García-Fandiño, R., Amorín, M., & Granja, J. (2016). Anion recognition self-assembly α,γ-cyclic peptide to form spherical clusters. Angewandte Chemie internationa edition,55(14):4504-8. Doi: 10.1002/anie.201511857 |
Abstract: | A cyclic octapeptide composed of hydroxy-functionalized γ-amino acids folds in a "V-shaped" conformation that allows the selective recognition of anions such as chloride, nitrate, and carbonate. The process involves the simultaneous self-assembly of six peptide subunits and the recognition of four anions to form a tetrahedral structure, in which the anions are located at the corners of the resulting structure. Each anion is coordinated to three different peptides. The structure was fully characterized by several techniques, including NMR spectroscopy and X-ray diffraction, and the material was able to facilitate the transmembrane transport of chloride ions |
Publisher version: | https://doi.org/10.1002/anie.201511857 |
URI: | http://hdl.handle.net/10347/16736 |
DOI: | 10.1002/anie.201511857 |
ISSN: | 1433-7851 |
E-ISSN: | 1521-3773 |
Rights: | © 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim |
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