Working memory over a six-year period in young binge drinkers
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Title: | Working memory over a six-year period in young binge drinkers |
Author: | Carbia Sinde, Carina Cadaveira Mahía, Fernando López Caneda, Eduardo Guillermo Caamaño Isorna, Francisco Rodríguez Holguín, Socorro Corral Varela, María Montserrat |
Affiliation: | Universidade de Santiago de Compostela. Departamento de Psicoloxía Clínica e Psicobioloxía Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía e Saúde Pública |
Subject: | Adolescence | Alcohol | Working memory | Longitudinal | Heavy drinking | Binge drinking | Follow-up study | Adolescencia | Memoria de trabajo | Consumo intensivo de alcohol | |
Date of Issue: | 2017 |
Publisher: | Elsevier Masson |
Citation: | Carbia C; Cadaveira F; López-Caneda E; Caamaño F; Rodríguez Holguín S; Corral M (2017) Working memory over a six-year period in young binge drinkers. Alcohol, 61, 17-23. Doi: 10.1016/j.alcohol.2017.01.013 |
Abstract: | Adolescence and early adulthood are periods of particular vulnerability to the neurotoxic effects of alcohol. Young people with alcohol-use disorders display deficits in working memory (WM). This function is supported by the prefrontal cortex, a late-maturing brain region. However, little is known about the progression of cognitive dysfunctions associated with a binge-drinking (BD) pattern of alcohol consumption among non-clinical adolescents. The objective of this study was to analyze the relationship between BD trajectory and WM in university students. An initial sample of 155 male and female first-year university students was followed prospectively over 6 years. The participants were classified as stable non-BDs, stable BDs, and ex-BDs, according to the third item of the Alcohol Use Disorders Identification Test (AUDIT). WM was assessed using the Self-Ordered Pointing Task. Generalized linear mixed models were applied. The results showed that stable BDs committed more total perseverative errors and showed a lower WM span in the difficult blocks than stable non-BDs. Difficulties in WM span showed some improvement, whereas perseveration errors remained constant throughout the follow-ups in the stable BDs. There were no significant differences between ex-BDs and non-BDs. In conclusion, stable BD is associated with WM deficits, particularly perseverations and low WM span in demanding trials, when compensatory mechanisms may no longer be successful. The partial improvement in WM span may support the notion of a neuromaturational delay, whereas the temporal stability of perseveration deficits may reflect either neurotoxic effects of alcohol or premorbid characteristics. Abandoning the BD pattern of alcohol consumption may lead to partial recovery |
Publisher version: | https://doi.org/10.1016/j.alcohol.2017.01.013 |
URI: | http://hdl.handle.net/10347/16823 |
DOI: | 10.1016/j.alcohol.2017.01.013 |
ISSN: | 0741-8329 |
E-ISSN: | 1873-6823 |
Rights: | © 2017 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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