Oligoalanine helical callipers for cell penetration
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Title: | Oligoalanine helical callipers for cell penetration |
Author: | Pazo Pascual, Marta Juanes Carrasco, Marisa Lostalé Seijo, Irene Montenegro García, Javier |
Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Date of Issue: | 2018-05-23 |
Publisher: | Royal Society of Chemistry |
Citation: | Pazo, M., Juanes, M., Lostalé-Seijo, I., & Montenegro, J. (2018). Oligoalanine helical callipers for cell penetration. Chemical Communications, 54(50), 6919-6922. doi: 10.1039/c8cc02304b |
Abstract: | Even for short peptides that are enriched in basic amino acids, the large chemical space that can be spanned by combinations of natural amino acids hinders the rational design of cell penetrating peptides. We here report on short oligoalanine scaffolds for the fine-tuning of peptide helicity in different media and the study of cell penetrating properties. This strategy allowed the extraction of the structure/activity features required for maximal membrane interaction and cellular penetration at minimal toxicity. These results confirmed oligoalanine helical callipers as optimal scaffolds for the rational design and the identification of cell penetrating peptides |
Description: | This is the accepted manuscript of the following article: Pazo, M., Juanes, M., Lostalé-Seijo, I., & Montenegro, J. (2018). Oligoalanine helical callipers for cell penetration. Chem. Commun., 2018, 54, 6919-6922. doi: 10.1039/c8cc02304b. This article may be used for non-commercial purposes in accordance with RSC Terms and Conditions for self-archiving |
Publisher version: | https://doi.org/10.1039/c8cc02304b |
URI: | http://hdl.handle.net/10347/16956 |
DOI: | 10.1039/C8CC02304B |
ISSN: | 1359-7345 |
E-ISSN: | 1364-548X |
Rights: | © Royal Society of Chemistry 2018. This article may be used for non-commercial purposes in accordance with RSC Terms and Conditions for self-archiving |
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