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dc.contributor.authorPazo Pascual, Marta
dc.contributor.authorJuanes Carrasco, Marisa
dc.contributor.authorLostalé Seijo, Irene
dc.contributor.authorMontenegro García, Javier
dc.date.accessioned2018-07-05T07:31:02Z
dc.date.available2018-11-23T02:00:10Z
dc.date.issued2018-05-23
dc.identifier.citationPazo, M., Juanes, M., Lostalé-Seijo, I., & Montenegro, J. (2018). Oligoalanine helical callipers for cell penetration. Chemical Communications, 54(50), 6919-6922. doi: 10.1039/c8cc02304b
dc.identifier.issn1359-7345
dc.identifier.urihttp://hdl.handle.net/10347/16956
dc.descriptionThis is the accepted manuscript of the following article: Pazo, M., Juanes, M., Lostalé-Seijo, I., & Montenegro, J. (2018). Oligoalanine helical callipers for cell penetration. Chem. Commun., 2018, 54, 6919-6922. doi: 10.1039/c8cc02304b. This article may be used for non-commercial purposes in accordance with RSC Terms and Conditions for self-archiving
dc.description.abstractEven for short peptides that are enriched in basic amino acids, the large chemical space that can be spanned by combinations of natural amino acids hinders the rational design of cell penetrating peptides. We here report on short oligoalanine scaffolds for the fine-tuning of peptide helicity in different media and the study of cell penetrating properties. This strategy allowed the extraction of the structure/activity features required for maximal membrane interaction and cellular penetration at minimal toxicity. These results confirmed oligoalanine helical callipers as optimal scaffolds for the rational design and the identification of cell penetrating peptides
dc.description.sponsorshipThis work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [CTQ2014-59646-R, SAF2017-89890-R], the Xunta de Galicia (ED431G/09, ED431C 2017/25 and 2016-AD031) and the ERDF. M. P. thanks the Xunta de Galicia for a pre-doctoral fellowship (ED481A-2017/142), and M. J. MINECO for a F. P. I. fellowship. J. M. received a Ramón y Cajal (RYC-2013-13784), an ERC Starting Investigator Grant (DYNAP-677786) and a Young Investigator Grant from the Human Frontier Science Research Program (RGY0066/2017)
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/677786
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-89890-R/ES/PEPTIDOS HIBRIDOS PARA EL TRANSPORTE SELECTIVO Y ENTREGA DE PROTEINAS TERAPEUTICAS
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2014-59646-R/ES/NUEVOS DISEÑOS CON CONTROL TOPOLOGICO DE PEPTIDOS PENETRANTES EN CELULAS
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2013-13784/ES
dc.rights© Royal Society of Chemistry 2018. This article may be used for non-commercial purposes in accordance with RSC Terms and Conditions for self-archiving
dc.titleOligoalanine helical callipers for cell penetration
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1039/C8CC02304B
dc.relation.publisherversionhttps://doi.org/10.1039/c8cc02304b
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.e-issn1364-548X
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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