Click Chemistry for Drug Delivery Nanosystems
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Título: | Click Chemistry for Drug Delivery Nanosystems |
Autor/a: | Lallana, Enrique Sousa Hervés, Ana Fernández Trillo, Francisco |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Palabras chave: | Bioconjugation | Click chemistry | CuAAC | Drug delivery | Nanostructure | |
Data: | 2012 |
Editor: | Springer |
Cita bibliográfica: | Lallana, E., Sousa-Herves, A., Fernandez-Trillo, F. et al. Pharm Res (2012) 29: 1. https://doi.org/10.1007/s11095-011-0568-5 |
Resumo: | The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click reactions have been reported for the preparation and functionalization of polymeric micelles and nanoparticles, liposomes and polymersomes, capsules, microspheres, metal and silica nanoparticles, carbon nanotubes and fullerenes, or bionanoparticles. Among these click processes, Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) has attracted most attention based on its high orthogonality, reliability, and experimental simplicity for non-specialists. A renewed interest in the use of efficient classical transformations has been also observed (e.g., thiol-ene coupling, Michael addition, Diels-Alder). Special emphasis is also devoted to critically discuss the click concept, as well as practical aspects of application of CuAAC to ensure efficient and harmless bioconjugation |
Descrición: | This is a post-peer-review, pre-copyedit version of an article published in Pharmaceutical Research. The final authenticated version is available online at: https://doi.org/10.1007/s11095-011-0568-5 |
Versión do editor: | https://doi.org/10.1007/s11095-011-0568-5 |
URI: | http://hdl.handle.net/10347/16965 |
DOI: | 10.1007/s11095-011-0568-5 |
ISSN: | 0724-8741 |
E-ISSN: | 1573-904X |
Dereitos: | © Springer Science+Business Media, LLC 2011 |
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