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dc.contributor.authorSousa Hervés, Ana
dc.contributor.authorNovoa Carballal, Ramón
dc.contributor.authorRiguera Vega, Ricardo
dc.contributor.authorFernández Megía, Eduardo
dc.date.accessioned2018-07-05T12:28:26Z
dc.date.available2018-07-05T12:28:26Z
dc.date.issued2014
dc.identifier.citationSousa-Herves, A., Novoa-Carballal, R., Riguera, R. et al. AAPS J (2014) 16: 948. https://doi.org/10.1208/s12248-014-9642-3
dc.identifier.urihttp://hdl.handle.net/10347/16967
dc.descriptionThis is a post-peer-review, pre-copyedit version of an article published in The AAPS Journal. The final authenticated version is available online at: https://doi.org/10.1208/s12248-014-9642-3
dc.description.abstractDendrimers are synthetic macromolecules composed of repetitive layers of branching units that emerge from a central core. They are characterized by a tunable size and precise number of peripheral groups which determine their physicochemical properties and function. Their high multivalency, functional surface, and globular architecture with diameters in the nanometer scale makes them ideal candidates for a wide range of applications. Gallic acid-triethylene glycol (GATG) dendrimers have attracted our attention as a promising platform in the biomedical field because of their high tunability and versatility. The presence of terminal azides in GATG dendrimers and poly(ethylene glycol) (PEG)-dendritic block copolymers allows their efficient functionalization with a variety of ligands of biomedical relevance including anionic and cationic groups, carbohydrates, peptides, or imaging agents. The resulting functionalized dendrimers have found application in drug and gene delivery, as antiviral agents and for the treatment of neurodegenerative diseases, in diagnosis and as tools to study multivalent carbohydrate recognition and dendrimer dynamics. Herein, we present an account on the preparation and recent applications of GATG dendrimers in these fields
dc.description.sponsorshipThe authors wish to acknowledge past and present lab members who have contributed to the development of dendrimers in our group. This work was financially supported by the Spanish Government (CTQ2009-10963, CTQ2012-34790, CTQ2009-14146-C02-02, CTQ2012-33436) and the Xunta de Galicia (10CSA209021PR and CN2011/037)
dc.language.isoeng
dc.publisherSpringer
dc.rights© American Association of Pharmaceutical Scientists 2014
dc.subjectBlock copolymer
dc.subjectDendrimer
dc.subjectDrug delivery
dc.subjectMultivalency
dc.subjectNMR
dc.titleGATG Dendrimers and PEGylated Block Copolymers: from Synthesis to Bioapplications
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1208/s12248-014-9642-3
dc.relation.publisherversionhttps://doi.org/10.1208/s12248-014-9642-3
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.e-issn1550-7416
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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