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dc.contributor.author | Gonzalo, Teresa |
dc.contributor.author | Lollo, Giovanna |
dc.contributor.author | García-Fuentes, Marcos |
dc.contributor.author | Torres, Dolores |
dc.contributor.author | Correa, Juan |
dc.contributor.author | Riguera Vega, Ricardo |
dc.contributor.author | Fernández Megía, Eduardo |
dc.contributor.author | Calvo, Pilar |
dc.contributor.author | Avilés, Pablo |
dc.contributor.author | Guillén, Maria José |
dc.contributor.author | Alonso Fernández, María José |
dc.date.accessioned | 2018-07-06T08:47:26Z |
dc.date.available | 2018-07-06T08:47:26Z |
dc.date.issued | 2013-07 |
dc.identifier.citation | Gonzalo, T., Lollo, G., Garcia-Fuentes, M., Torres, D., Correa, J., & Riguera, R. et al. (2013). A new potential nano-oncological therapy based on polyamino acid nanocapsules. Journal Of Controlled Release, 169(1-2), 10-16. doi: 10.1016/j.jconrel.2013.03.037 |
dc.identifier.issn | 0168-3659 |
dc.identifier.uri | http://hdl.handle.net/10347/16975 |
dc.description.abstract | A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) nanocapsules, and present the in vivo pharmacokinetics/toxicity proof-of-concept for the anticancer drug plitidepsin. These novel nanocapsules were prepared using a modified solvent displacement technique where the polyamino acid was electrostatically deposited onto the lipid core. The nanocapsules exhibited an average size of 200 nm, a negative zeta potential and a great capacity for the encapsulation of plitidepsin (encapsulation efficiency above 90%). In addition, the nanocapsules could be freeze-dried and showed an adequate stability profile upon storage. Finally, the in vivo proof-of-concept studies performed in mice indicated that the encapsulation provided the drug with a prolonged blood circulation and a significantly reduced toxicity. In fact, the maximum tolerated dose of the nanoencapsulated drug was more than 3 times that of the reference formulation (Cremophor® EL plitidepsin solution). Overall, beyond the value of this specific formulation, the work reported here represents the evidence of the potential of polyamino acid nanocapsules in nano-oncological therapy |
dc.description.sponsorship | The authors would like to acknowledge financial support from CENIT-NANOFAR XS53 project, PharmaMar, Spain, the Ministry of Sciences and Innovation ((CTQ2009-10963), the Xunta de Galicia (Competitive Reference Groups-FEDER funds Ref. 2010/18, and CN2011/037) and the European Commission FP7 EraNet — EuroNanoMed Program-Instituto Carlos III (Lymphotarg proyect, Ref. PS09/02670). Giovanna Lollo has a fellowship from the Ministry of Education of Spain. Marcos Garcia Fuentes acknowledges an Isidro Parga Pondal Fellowship from Xunta de Galicia |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.rights | © 2013 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http:// creativecommons.org/licenses/by-nc-nd/4.0/) |
dc.subject | Nanomedicines |
dc.subject | Long-circulating nanocarriers |
dc.subject | Nanocapsules |
dc.subject | Polyglutamic acid |
dc.subject | Cancer |
dc.title | A new potential nano-oncological therapy based on polyamino acid nanocapsules |
dc.type | journal article |
dc.identifier.doi | 10.1016/j.jconrel.2013.03.037 |
dc.relation.publisherversion | https://doi.org/10.1016/j.jconrel.2013.03.037 |
dc.type.hasVersion | AM |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Farmacia e Tecnoloxía Farmacéutica |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
dc.description.peerreviewed | SI |
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