High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides
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| Title: | High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides |
| Author: | Gamba, Ilaria Salvadó, Iria Brissos, Rosa F. Gamez, Patrick Brea Floriani, José Manuel Loza García, María Isabel Vázquez Sentís, Marco Eugenio Vázquez López, Miguel |
| Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Inorgánica Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Date of Issue: | 2016 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Gamba, I., Salvadó, I., Brissos, R., Gamez, P., Brea, J., & Loza, M. et al. (2016). High-affinity sequence-selective DNA binding by iridium(iii) polypyridyl organometallopeptides. Chemical Communications, 52(6), 1234-1237. doi: 10.1039/c5cc07619f |
| Abstract: | We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines |
| Publisher version: | https://doi.org/10.1039/C5CC07619F |
| URI: | http://hdl.handle.net/10347/17021 |
| DOI: | 10.1039/C5CC07619F |
| ISSN: | 1359-7345 |
| E-ISSN: | 1364-548X |
| Rights: | © The Royal Society of Chemistry 2016 |
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