Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides
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| Title: | Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides |
| Author: | Bouzada, David Salvadó, Iria Barka, Ghofrane Rama, Gustavo Martínez Costas, José Manuel Lorca, Romina Somoza, Álvaro Melle-Franco, Manuel Vázquez Sentís, Marco Eugenio Vázquez López, Miguel |
| Affiliation: | Universidade de Santiago de Compostela. Departamento de Química Orgánica Universidade de Santiago de Compostela. Departamento de Química Inorgánica Universidade de Santiago de Compostela. Departamento de Bioquímica e Bioloxía Molecular Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares |
| Date of Issue: | 2018 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Bouzada, D., Salvadó, I., Barka, G., Rama, G., Martínez-Costas, J., & Lorca, R. et al. (2018). Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides. Chemical Communications, 54(6), 658-661. doi: 10.1039/c7cc08286j |
| Abstract: | A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex structures over those lacking it, and also that the interplay between the octoarginine functionalization and the ancillary ligand in the complex has an essential role in the recognition process. Furthermore, the oligoarginine metallopeptides are also efficiently internalized, causing cell death with signs of apoptosis |
| Publisher version: | https://doi.org/10.1039/C7CC08286J |
| URI: | http://hdl.handle.net/10347/17024 |
| DOI: | 10.1039/C7CC08286J |
| ISSN: | 1359-7345 |
| E-ISSN: | 1364-548X |
| Rights: | © The Royal Society of Chemistry 2018 |
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