Now showing items 11-21 of 21

    • Host-Guest Complexation Studied by Fluorescence Correlation Spectroscopy: Adamantane–Cyclodextrin Inclusion 

      Granadero, Daniel; Bordello Malde, Jorge; Pérez Alvite, María Jesús; Novo Rodríguez, María de la Merced; Al-Soufi, Wajih (MDPI, 2010)
      The host-guest complexation between an Alexa 488 labelled adamantane derivative and β-cyclodextrin is studied by Fluorescence Correlation Spectroscopy (FCS). A 1:1 complex stoichiometry and a high association equilibrium ...
    • In Vivo Theranostics at the Peri-Infarct Region in Cerebral Ischemia 

      Agulla Freire, Jesús; Brea López, David; Campos Pérez, Francisco; Sobrino Moreiras, Tomás; Argibay González, Bárbara; Al-Soufi, Wajih; Blanco González, Miguel; Castillo Sánchez, José Antonio; Ramos Cabrer, Pedro (Ivyspring International Publisher, 2014)
      The use of theranostics in neurosciences has been rare to date because of the limitations imposed on the free delivery of substances to the brain by the blood-brain barrier. Here we report the development of a theranostic ...
    • A model for monomer and micellar concentrations in surfactant solutions: application to conductivity, NMR, diffusion, and surface tension data 

      Al-Soufi, Wajih; Piñeiro Maseda, Lucas; Novo Rodríguez, María de la Merced (Elsevier, 2012)
      An empirical model for the concentrations of monomeric and micellized surfactants in solution is presented as a consistent approach for the quantitative analysis of data obtained with different experimental techniques from ...
    • Moderately Strong Photoacid Dissociates in Alcohols with High Transient Concentration of the Proton-Transfer Contact Pair 

      Brenlla, Alfonso; Veiga Gutiérrez, Manoel; Ríos Rodríguez, M. Carmen; Rodríguez-Prieto, Flor; Mosquera González, Manuel; Pérez Lustres, José Luis (American Chemical Society, 2014)
      Proton transfer from strong photoacids to hydroxylic solvents is much under debate. Experimentally, the main issue stems from relaxation and diffusion processes that are concomitant with ultrafast proton transfer and blur ...
    • Photoinduced Proton and Charge Transfer in 2‑(2′- Hydroxyphenyl)imidazo[4,5‑b]pyridine 

      Brenlla, Alfonso; Veiga Gutiérrez, Manoel; Pérez Lustres, José Luis; Ríos Rodríguez, M. Carmen; Rodríguez-Prieto, Flor; Mosquera González, Manuel (American Chemical Society, 2013)
      This paper deals with the interplay between solvent properties and isomerism of 2-(2′-hydroxyphenyl)imidazo[4,5-b]pyridine (1), and the proton and charge-transfer processes that the different isomers undergo in the ...
    • Photophysical study of Thioflavin T as fluorescence marker of amyloid fibrils 

      Freire Rodríguez, Sonia; Araujo, Marcus H. de; Al-Soufi, Wajih; Novo Rodríguez, María de la Merced (Elsevier, 2014)
      Thioflavin T is a highly sensitive fluorescent marker of amyloid fibrils that has been widely used for in vitro biomedical assays. However, neither its complex photophysical behavior nor its binding mode to amyloid fibrils ...
    • Spectroscopic characterization of mitochondrial G-quadruplexes 

      Illodo, Sara; Pérez González, Cibrán; Barcia, Ramiro; Rodriguez-Prieto, Flor ; Al-Soufi, Wajih; Novo Rodríguez, Mercedes (MDPI, 2022)
      Guanine quadruplexes (G4s) are highly polymorphic four-stranded structures formed within guanine-rich DNA and RNA sequences that play a crucial role in biological processes. The recent discovery of the first G4 structures ...
    • A surfactant concentration model for the systematic determination of the critical micellar concentration and the transition width 

      Al-Soufi, Wajih; Novo Rodríguez, Mercedes (MDPI, 2021)
      The critical micellar concentration (cmc) is a fundamental property of surfactant solutions. Many proposed methods for the definition and determination of the cmc from property-concentration plots yield values, which depend ...
    • Towards Ratiometric Sensing of Amyloid Fibrils In Vitro 

      Freire Rodríguez, Sonia; Rodríguez Prieto, María de la Flor; Ríos Rodríguez, María del Carmen; Penedo Esteiro, Juan Carlos; Al-Soufi, Wajih; Novo Rodríguez, María de la Merced (Wiley, 2015)
      The aggregation of amyloid‐β peptide and its accumulation in the human brain has an important role in the etiology of Alzheimer’s disease. Thioflavin T has been widely used as a fluorescent marker for these amyloid aggregates. ...
    • Ultrafast deactivation of bilirubin: dark intermediates and two-photon isomerization 

      Carreira Blanco, Carlos; Singer, Patrick; Diller, Rolf; Pérez Lustres, José Luis (Royal Society of Chemistry, 2016)
      Bilirubin is a neurotoxic product responsible for neonatal jaundice, which is generally treated by phototherapy. The photoreaction involves ultrafast internal conversion via an elusive intermediate and Z–E isomerization ...
    • Unveiling the multi-step solubilization mechanism of sub-micron size vesicles by detergents 

      Dalgarno, Paul A.; Juan-Colás, José; Hedley, Gordon J.; Piñeiro Maseda, Lucas; Novo Rodríguez, María de la Merced; Pérez González, Cibrán; Samuel, Ifor D. W.; Leake, Mark C.; Johnson, Steven; Al-Soufi, Wajih; Penedo, J. Carlos; Quinn, Steven D. (Nature Publishing Group, 2019)
      The solubilization of membranes by detergents is critical for many technological applications and has become widely used in biochemistry research to induce cell rupture, extract cell constituents, and to purify, reconstitute ...





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