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dc.contributor.authorGranadero, Daniel
dc.contributor.authorBordello Malde, Jorge
dc.contributor.authorPérez Alvite, María Jesús
dc.contributor.authorNovo Rodríguez, María de la Merced
dc.contributor.authorAl-Soufi, Wajih
dc.date.accessioned2018-07-23T12:27:03Z
dc.date.available2018-07-23T12:27:03Z
dc.date.issued2010
dc.identifier.citationGranadero, D.; Bordello, J.; Pérez-Alvite, M.J.; Novo, M.; Al-Soufi, W. Host-Guest Complexation Studied by Fluorescence Correlation Spectroscopy: Adamantane–Cyclodextrin Inclusion. Int. J. Mol. Sci. 2010, 11, 173-188
dc.identifier.urihttp://hdl.handle.net/10347/17069
dc.description.abstractThe host-guest complexation between an Alexa 488 labelled adamantane derivative and β-cyclodextrin is studied by Fluorescence Correlation Spectroscopy (FCS). A 1:1 complex stoichiometry and a high association equilibrium constant of K = 5.2 × 104 M-1 are obtained in aqueous solution at 25 °C and pH = 6. The necessary experimental conditions are discussed. FCS proves to be an excellent method for the determination of stoichiometry and association equilibrium constant of this type of complexes, where both host and guest are nonfluorescent and which are therefore not easily amenable to standard fluorescence spectroscopic methods
dc.description.sponsorshipJ.B. thanks the Ministerio de Ciencia e Innovación for a research scholarship. M.J.P.A thanks the Spanish MICINN for her FPI Fellowship. M.N. and W.A. thank the Ministerio de Ciencia e Innovación and the Xunta de Galicia for financial support (CTQ2004-07683-C02-02, INCITE07PXI209034ES, INCITE08E1R209060ES)
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subjectFluorescence correlation spectroscopy
dc.subjectHost-guest chemistry
dc.subjectAdamantane
dc.subjectCyclodextrin
dc.titleHost-Guest Complexation Studied by Fluorescence Correlation Spectroscopy: Adamantane–Cyclodextrin Inclusion
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.3390/ijms11010173
dc.relation.publisherversionhttps://doi.org/10.3390/ijms11010173
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1422-0067
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Física
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)
Except where otherwise noted, this item's license is described as  © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)





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