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dc.contributor.authorMallo López, Sabela Carme
dc.contributor.authorIsmail, Zahinoor
dc.contributor.authorPereiro Rozas, Arturo José
dc.contributor.authorFacal Mayo, David
dc.contributor.authorLojo Seoane, Cristina
dc.contributor.authorCampos Magdaleno, María
dc.contributor.authorJuncos Rabadán, Onésimo
dc.identifier.citationMallo, S., Ismail, Z., Pereiro, A., Facal, D., Lojo-Seoane, C., Campos-Magdaleno, M., & Juncos-Rabadán, O. (2018). Assessing Mild Behavioral Impairment with the Mild Behavioral Impairment-Checklist in People with Mild Cognitive Impairment. Journal Of Alzheimer's Disease, 1-13. doi: 10.3233/jad-180131
dc.description.abstractBackground: Neuropsychiatric symptoms (NPS) are non-cognitive, behavioral, or psychiatric symptoms, common in mild cognitive impairment (MCI) and associated with a higher risk of dementia. Mild behavioral impairment (MBI) is a validated diagnostic entity, that describes the emergence of later life NPS in pre-dementia states. The Mild Behavioral Impairment Checklist (MBI-C) is the first measure developed to assess MBI. Objective: To estimate the prevalence of MBI in people with MCI and to study the score distribution, sensitivity, specificity, diagnostic utility of the MBI-C, and its correlations with neuropsychological tests. Methods: One hundred eleven MCI participants were evaluated with the Questionnaire for Subjective Memory Complaints (QSMC), Mini-Mental State Examination, Cambridge Cognitive Assessment-Revised, Neuropsychiatric Inventory- Questionnaire (NPI-Q), Geriatric Depression Scale-15 items (GDS-15), Lawton and Brody Index, and the MBI-C, which was administered by phone to participants’ informants. Descriptive, logistic regression, ROC curve, and bivariate correlations analyses were performed. Results: MBI diagnosis prevalence was 14.2%. The total MBI-C score differentiated people with MBI at a cutoff-point of 6.5, optimizing sensitivity and specificity. MBI-C total score correlated positively with NPI-Q, QSMC, GDS-15, and Lawton and Brody Index. Conclusion: The total MBI-C score, obtained by phone administration, is sensitive for detecting MBI in people with MCI. The MBI-C scores indicated that MCI participants had subtle NPS that were correlated to their subjective memory complaints reported by informants, depressive symptoms, and negatively with Instrumental Activities of Daily Living. Further research should be done to clarify the predictive role of NPS in MCI for incident dementia
dc.description.sponsorshipThe study was funded by the Spanish Ministry of Economy and Competitiveness (ref. PSI2014-55316- C3-1-R) and the Galician Autonomous Government Grant (ref. ED431C2017/27). The first author is funded by a fellowship from the Spanish Ministry of Economy and Competitiveness (ref. BES-2015- 071253)
dc.publisherIOS Press
dc.rights© 2018 IOS Press and the authors. All rights reserved
dc.subjectBehavioral and psychological symptoms of dementia
dc.subjectMild behavioral impairment
dc.subjectMild cognitive impairment
dc.subjectNeuropsychiatric symptoms
dc.subjectPreclinical dementia
dc.subjectProdromal dementia
dc.titleAssessing Mild Behavioral Impairment with the Mild Behavioral Impairment-Checklist in People with Mild Cognitive Impairment
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Psicoloxía Evolutiva e da Educación

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