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dc.contributor.authorVarela-Eirin, Marta
dc.contributor.authorVarela-Vazquez, Adrian
dc.contributor.authorRodríguez-Candela Mateos, Marina
dc.contributor.authorVila-Sanjurjo, Anton
dc.contributor.authorFonseca, Eduardo
dc.contributor.authorMascareñas Cid, José Luis
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMayan, Maria D.
dc.date.accessioned2018-10-08T11:19:01Z
dc.date.available2018-10-08T11:19:01Z
dc.date.issued2017-04
dc.identifier.citationVarela-Eirin, M., Varela-Vazquez, A., Rodríguez-Candela Mateos, M., Vila-Sanjurjo, A., Fonseca, E., & Mascareñas, J. et al. (2017). Recruitment of RNA molecules by connexin RNA-binding motifs: Implication in RNA and DNA transport through microvesicles and exosomes. Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research, 1864(4), 728-736. doi: 10.1016/j.bbamcr.2017.02.001
dc.identifier.issn0167-4889
dc.identifier.urihttp://hdl.handle.net/10347/17407
dc.description.abstractConnexins (Cxs) are integral membrane proteins that form high-conductance plasma membrane channels, allowing communication from cell to cell (via gap junctions) and from cells to the extracellular environment (via hemichannels). Initially described for their role in joining excitable cells (nerve and muscle), gap junctions (GJs) are found between virtually all cells in solid tissues and are essential for functional coordination by enabling the direct transfer of small signalling molecules, metabolites, ions, and electrical signals from cell to cell. Several studies have revealed diverse channel-independent functions of Cxs, which include the control of cell growth and tumourigenicity. Connexin43 (Cx43) is the most widespread Cx in the human body. The myriad roles of Cx43 and its implication in the development of disorders such as cancer, inflammation, osteoarthritis and Alzheimer's disease have given rise to many novel questions. Several RNA- and DNA-binding motifs were predicted in the Cx43 and Cx26 sequences using different computational methods. This review provides insights into new, ground-breaking functions of Cxs, highlighting important areas for future work such as transfer of genetic information through extracellular vesicles. We discuss the implication of potential RNA- and DNA-binding domains in the Cx43 and Cx26 sequences in the cellular communication and control of signalling pathways
dc.description.sponsorshipThis work was supported in part through funding from the Society for Research on Bone and Mineral Metabolism - Grant number FEIOMM2016 (to M.D.M.), by grant PRECIPITA-2015-000139 from the FECYT-Ministry of Economy and Competitiveness (to M.D.M), by grants PI13/00591 and PI16/00035 from the Health Institute “Carlos III” (ISCIII, Spain) and co-financed by the European Regional Development Fund, “A way of making Europe” from the European Union (to M.D.M.), by a grant from Xunta de Galicia (pre-doctoral fellowship) to M.V.-E., and by a grant from the Ministry of Education, Culture and Sports, Spain (FPU grant to M.R.-C.M.)
dc.language.isoeng
dc.publisherElsevier
dc.rights© 2017 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Contents lists available at ScienceDirectBiochimica et Biophysica Actajournal homepage: www.elsevier.com/locate/bbamcr
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectConnexin43
dc.subjectConnexin26
dc.subjectCellular communication
dc.subjectMicrovesicles
dc.subjectExosomes
dc.subjectRNA-binding domains
dc.titleRecruitment of RNA molecules by connexin RNA-binding motifs: Implication in RNA and DNA transport through microvesicles and exosomes
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1016/j.bbamcr.2017.02.001
dc.relation.publisherversionhttps://doi.org/10.1016/j.bbamcr.2017.02.001
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Inorgánica
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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© 2017 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Contents lists available at ScienceDirectBiochimica et Biophysica Actajournal homepage: www.elsevier.com/locate/bbamcr
Except where otherwise noted, this item's license is described as  © 2017 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Contents lists available at ScienceDirectBiochimica et Biophysica Actajournal homepage: www.elsevier.com/locate/bbamcr





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