Synthetic materials at the forefront of gene delivery
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| Title: | Synthetic materials at the forefront of gene delivery |
| Author: | Lostalé Seijo, Irene Montenegro, Javier |
| Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Subject: | Gene delivery | Gene therapy | Nanoparticles | |
| Date of Issue: | 2018-09-21 |
| Publisher: | Springer Nature |
| Citation: | Lostalé-Seijo, I., & Montenegro, J. (2018). Synthetic materials at the forefront of gene delivery. Nature Reviews Chemistry, 2(10), 258-277. doi: 10.1038/s41570-018-0039-1 |
| Abstract: | The delivery of nucleic acids with transient activity for genetic engineering is a promising methodology with potential applications in the treatment of diseases ranging from cancer and infectious diseases to heritable disorders. Restoring the expression of a missing protein, correcting defective splicing of transcripts and silencing or modulating the expression of genes are powerful approaches that could have substantial benefits in biological research and medicine. Impressive progress in improving gene delivery has been made in the past decade, and several products have reached the market. However, translating the results of in vitro and preclinical studies into functional therapies is hindered by the suboptimal performance of gene delivery vehicles in capturing, protecting and delivering nucleic acid cargoes safely and efficaciously. Chemistry has a key role in the development of innovative synthetic materials to overcome the challenges of producing next-generation gene delivery therapies and protocols. In this Review, we discuss the latest chemical advances in the production of materials for the delivery of nucleic acids to cells and for gene therapy |
| Description: | This is the Author's Accepted Manuscript of the following article: Lostalé-Seijo, I., & Montenegro, J. (2018).
Synthetic materials at the forefront of gene delivery. Nature Reviews Chemistry. doi: 10.1038/s41570-018-0039-1 |
| Publisher version: | https://doi.org/10.1038/s41570-018-0039-1 |
| URI: | http://hdl.handle.net/10347/17429 |
| DOI: | 10.1038/s41570-018-0039-1 |
| E-ISSN: | 2397-3358 |
| Rights: | © 2018 Springer Nature |
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