Multi-residue determination of psychoactive pharmaceuticals, illicit drugs and related metabolites in wastewater by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
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Título: | Multi-residue determination of psychoactive pharmaceuticals, illicit drugs and related metabolites in wastewater by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry |
Autor/a: | González Mariño, Iria Castro Bustelo, Verónica Montes Goyanes, Rosa María Rodil Rodríguez, María del Rosario Lores, Ana Cela Torrijos, Rafael Quintana Álvarez, José Benito |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía Universidade de Santiago de Compostela. Instituto de Investigación e Análises Alimentarias |
Palabras chave: | Benzodiazepines | Antidepressants | Substances of abuse | Sewage analysis | Solid-phase extraction | Ultra-high performance liquid chromatography | |
Data: | 2018-07-30 |
Editor: | Elsevier |
Cita bibliográfica: | González-Mariño, I., Castro, V., Montes, R., Rodil, R., Lores, A., Cela, R., & Quintana, J. (2018). Multi-residue determination of psychoactive pharmaceuticals, illicit drugs and related metabolites in wastewater by ultra-high performance liquid chromatography-tandem mass spectrometry. Journal Of Chromatography A, 1569, 91-100. doi: 10.1016/j.chroma.2018.07.045 |
Resumo: | This study presents a new multi-residue analytical method for the simultaneous determination of 38 psychoactive drugs (including benzodiazepines, antidepressants and drugs of abuse) and related metabolites in raw wastewater. Potential analyte losses during sample filtration and stability in wastewater were evaluated. Analyte losses, especially for 12 compounds, were observed during filtration, indicating a strong sorption onto the filter material. In order to overcome this effect, filtered water samples were combined with methanolic washes of the corresponding filters and the resulting solutions were solid-phase extracted on mixed-mode (reverse-phase plus cation-exchange) sorbents. Extracts were analyzed by ultra-high performance liquid chromatography-tandem mass spectrometry. Quantification was performed by the internal standard method with isotopic labeled analogs. Recovery percentages varied between 65% and 137%; method quantification limits ranged between 0.2 and 22 ng/L in ultrapure water and between 0.3 and 30 ng/L in wastewater for all the analytes but three (for which they were ∼60–80 ng/L). The analysis of 24 h-composite samples collected during one week in the city of Santiago de Compostela demonstrated the ubiquity of 31 analytes, which were positively quantified in all samples. The highest concentrations were found for some of the antidepressants, with mean and maximum levels exceeding, in some cases, the levels previously reported in literature. This fact could be related to the additional washing step of the filters using methanol, which allowed to desorb retained analytes highlighting the importance of this step during the sample preparation protocol |
Descrición: | This is the Author’s Accepted Manuscript of the following article: González-Mariño, I., Castro, V., Montes, R., Rodil, R., Lores, A., Cela, R., & Quintana, J. (2018). Multi-residue determination of psychoactive pharmaceuticals, illicit drugs and related metabolites in wastewater by ultra-high performance liquid chromatography-tandem mass spectrometry. Journal Of Chromatography A, 1569, 91-100. doi: 10.1016/j.chroma.2018.07.045
© Elsevier 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license |
Versión do editor: | https://doi.org/10.1016/j.chroma.2018.07.045 |
URI: | http://hdl.handle.net/10347/17434 |
DOI: | 10.1016/j.chroma.2018.07.045 |
ISSN: | 0021-9673 |
Dereitos: | © Elsevier 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license |
Coleccións
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- ChromChem-Artigos [83]
- IIAQBUS-Artigos [77]
- QANB-Artigos [324]
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