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dc.contributor.authorGonzález Mariño, Iria
dc.contributor.authorCastro Bustelo, Verónica
dc.contributor.authorMontes Goyanes, Rosa María
dc.contributor.authorRodil Rodríguez, María del Rosario
dc.contributor.authorLores, Ana
dc.contributor.authorCela Torrijos, Rafael
dc.contributor.authorQuintana Álvarez, José Benito
dc.date.accessioned2018-10-12T11:29:39Z
dc.date.available2020-07-30T01:00:08Z
dc.date.issued2018-07-30
dc.identifier.citationGonzález-Mariño, I., Castro, V., Montes, R., Rodil, R., Lores, A., Cela, R., & Quintana, J. (2018). Multi-residue determination of psychoactive pharmaceuticals, illicit drugs and related metabolites in wastewater by ultra-high performance liquid chromatography-tandem mass spectrometry. Journal Of Chromatography A, 1569, 91-100. doi: 10.1016/j.chroma.2018.07.045
dc.identifier.issn0021-9673
dc.identifier.urihttp://hdl.handle.net/10347/17434
dc.descriptionThis is the Author’s Accepted Manuscript of the following article: González-Mariño, I., Castro, V., Montes, R., Rodil, R., Lores, A., Cela, R., & Quintana, J. (2018). Multi-residue determination of psychoactive pharmaceuticals, illicit drugs and related metabolites in wastewater by ultra-high performance liquid chromatography-tandem mass spectrometry. Journal Of Chromatography A, 1569, 91-100. doi: 10.1016/j.chroma.2018.07.045 © Elsevier 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
dc.description.abstractThis study presents a new multi-residue analytical method for the simultaneous determination of 38 psychoactive drugs (including benzodiazepines, antidepressants and drugs of abuse) and related metabolites in raw wastewater. Potential analyte losses during sample filtration and stability in wastewater were evaluated. Analyte losses, especially for 12 compounds, were observed during filtration, indicating a strong sorption onto the filter material. In order to overcome this effect, filtered water samples were combined with methanolic washes of the corresponding filters and the resulting solutions were solid-phase extracted on mixed-mode (reverse-phase plus cation-exchange) sorbents. Extracts were analyzed by ultra-high performance liquid chromatography-tandem mass spectrometry. Quantification was performed by the internal standard method with isotopic labeled analogs. Recovery percentages varied between 65% and 137%; method quantification limits ranged between 0.2 and 22 ng/L in ultrapure water and between 0.3 and 30 ng/L in wastewater for all the analytes but three (for which they were ∼60–80 ng/L). The analysis of 24 h-composite samples collected during one week in the city of Santiago de Compostela demonstrated the ubiquity of 31 analytes, which were positively quantified in all samples. The highest concentrations were found for some of the antidepressants, with mean and maximum levels exceeding, in some cases, the levels previously reported in literature. This fact could be related to the additional washing step of the filters using methanol, which allowed to desorb retained analytes highlighting the importance of this step during the sample preparation protocol
dc.language.isoeng
dc.publisherElsevier
dc.rights© Elsevier 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBenzodiazepines
dc.subjectAntidepressants
dc.subjectSubstances of abuse
dc.subjectSewage analysis
dc.subjectSolid-phase extraction
dc.subjectUltra-high performance liquid chromatography
dc.titleMulti-residue determination of psychoactive pharmaceuticals, illicit drugs and related metabolites in wastewater by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1016/j.chroma.2018.07.045
dc.relation.publisherversionhttps://doi.org/10.1016/j.chroma.2018.07.045
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía
dc.contributor.affiliationUniversidade de Santiago de Compostela. Instituto de Investigación e Análises Alimentarias
dc.description.peerreviewedSI


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© Elsevier 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Except where otherwise noted, this item's license is described as  © Elsevier 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license





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