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dc.contributor.authorGonzález Villar, Alberto Jacobo
dc.contributor.authorSamartín Veiga, Noelia
dc.contributor.authorArias Gómez, Manuel
dc.contributor.authorCarrillo de la Peña, María Teresa
dc.date.accessioned2018-10-15T13:23:35Z
dc.date.available2018-10-15T13:23:35Z
dc.date.issued2017
dc.identifier.citationGonzalez-Villar, A. J., Samartin-Veiga, N., Arias, M., & Carrillo-de-la-Peña, M. T. (2017). Increased neural noise and impaired brain synchronization in fibromyalgia patients during cognitive interference. Scientific reports, 7(1), 5841.
dc.identifier.urihttp://hdl.handle.net/10347/17453
dc.description.abstractFibromyalgia (FM) and other chronic pain syndromes are associated with cognitive dysfunction and attentional deficits, but the neural basis of such alterations is poorly understood. Dyscognition may be related to high levels of neural noise, understood as increased random electrical fluctuations that impair neural communication; however, this hypothesis has not yet been tested in any chronic pain condition. Here we compared electroencephalographic activity (EEG) in 18 FM patients -with high self-reported levels of cognitive dysfunction- and 22 controls during a cognitive control task. We considered the slope of the Power Spectrum Density (PSD) as an indicator of neural noise. As the PSD slope is flatter in noisier systems, we expected to see shallower slopes in the EEG of FM patients. Higher levels of neural noise should be accompanied by reduced power modulation and reduced synchronization between distant brain locations after stimulus presentation. As expected, FM patients showed flatter PSD slopes. After applying a Laplacian spatial filter, we found reduced theta and alpha power modulation and reduced midfrontal-posterior theta phase synchronization. Results suggest higher neural noise and impaired local and distant neural coordination in the patients and support the neural noise hypothesis to explain dyscognition in FM
dc.description.sponsorshipThis work was supported by funding from the Galician Government (Consellería de Cultura, Educación e Ordenación Universitaria; axudas para a consolidación e Estruturación de unidades de investigación competitivas do Sistema universitario de Galicia [grant number GPC2014/047] and funding from the Spanish Government (Ministerio de Economía y Competitividad) [grant number PSI2013-45818-R]. A.G.V. was supported by a grant from the Fundación Ramón Dominguez
dc.language.isoeng
dc.publisherSpringer Nature
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PSI2013-45818-R/ES/BIOMARCADORES DE FIBROMIALGIA (FM):PERFIL GENETICO,CONTROL INHIBITORIO DEL DOLOR Y PROCESAMIENTO CEREBRAL DE ESTIMULOS DOLOROSOS Y EMOCIONALES EN FM
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectChronic pain
dc.subjectCognitive control
dc.subjectFibromyalgia
dc.titleIncreased neural noise and impaired brain synchronization in fibromyalgia patients during cognitive interference
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1038/s41598-017-06103-4
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-017-06103-4
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn2045-2322
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Psicoloxía Clínica e Psicobioloxía
dc.description.peerreviewedSI


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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/





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