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dc.contributor.author | Booth, Richard |
dc.contributor.author | Insua López, Ignacio |
dc.contributor.author | Bhak, Ghibom |
dc.contributor.author | Montenegro García, Javier |
dc.date.accessioned | 2018-10-29T09:58:08Z |
dc.date.available | 2019-10-25T01:00:08Z |
dc.date.issued | 2018 |
dc.identifier.citation | Booth, R., Insua, I., Bhak, G., & Montenegro, J. (2018). Self-Assembled Micro-Fibres by Oxime Connection of Linear Peptide Amphiphiles. Organic & Biomolecular Chemistry. doi: 10.1039/c8ob02243g |
dc.identifier.issn | 1477-0520 |
dc.identifier.uri | http://hdl.handle.net/10347/17628 |
dc.description.abstract | Linear peptide amphiphiles are excellent biocompatible scaffolds for the hierarchical self-assembly of one dimensional nanostructures in aqueous media. However, their structural exploration and screening of self-assembling properties is often limited by time-consuming synthesis and purification steps. We here describe the application of the oxime bond as a powerful synthetic tool towards the conjugation of peptide heads bearing a hydroxylamine group with hydrophobic aldehyde tails. This methodology allowed the quick prepraration of a small library of oxime-connected peptide amphiphiles, whose supramolecular screening revealed nano-to-micro fibrillation with dependency on their chemical structure. These results demonstrate the simplicity and the synthetic potential of the oxime conjugation for the preparation of peptide amphiphiles with improved self-assembling capabilities |
dc.description.sponsorship | This work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [CTQ2014-59646-R, SAF2017-89890-R], the Xunta de Galicia (ED431G/09, ED431C 2017/25 and 2016-AD031) and the ERDF. I.I. thanks the Spanish AEI for a Juan de la Cierva -Formación fellowship (FJCI-2017-31795). J.M. received a Ramón y Cajal (RYC-2013-13784), an ERC Starting Investigator Grant (DYNAP-677786) and a Young Investigator Grant from the Human Frontier Science Research Program (RGY0066/2017) |
dc.language.iso | eng |
dc.publisher | Royal Society of Chemistry |
dc.rights | © 2018 Royal Society of Chemistry |
dc.title | Self-Assembled Micro-Fibres by Oxime Connection of Linear Peptide Amphiphiles |
dc.type | journal article |
dc.identifier.doi | 10.1039/C8OB02243G |
dc.relation.publisherversion | https://doi.org/10.1039/C8OB02243G |
dc.type.hasVersion | AM |
dc.identifier.essn | 1477-0539 |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
dc.description.peerreviewed | SI |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/677786 |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-89890-R/ES/PEPTIDOS HIBRIDOS PARA EL TRANSPORTE SELECTIVO Y ENTREGA DE PROTEINAS TERAPEUTICAS |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2014-59646-R/ES/NUEVOS DISEÑOS CON CONTROL TOPOLOGICO DE PEPTIDOS PENETRANTES EN CELULAS |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2013-13784/ES |
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