Mostrar o rexistro simple do ítem

dc.contributor.authorBooth, Richard
dc.contributor.authorInsua López, Ignacio
dc.contributor.authorBhak, Ghibom
dc.contributor.authorMontenegro García, Javier
dc.date.accessioned2018-10-29T09:58:08Z
dc.date.available2019-10-25T01:00:08Z
dc.date.issued2018
dc.identifier.citationBooth, R., Insua, I., Bhak, G., & Montenegro, J. (2018). Self-Assembled Micro-Fibres by Oxime Connection of Linear Peptide Amphiphiles. Organic & Biomolecular Chemistry. doi: 10.1039/c8ob02243g
dc.identifier.issn1477-0520
dc.identifier.urihttp://hdl.handle.net/10347/17628
dc.description.abstractLinear peptide amphiphiles are excellent biocompatible scaffolds for the hierarchical self-assembly of one dimensional nanostructures in aqueous media. However, their structural exploration and screening of self-assembling properties is often limited by time-consuming synthesis and purification steps. We here describe the application of the oxime bond as a powerful synthetic tool towards the conjugation of peptide heads bearing a hydroxylamine group with hydrophobic aldehyde tails. This methodology allowed the quick prepraration of a small library of oxime-connected peptide amphiphiles, whose supramolecular screening revealed nano-to-micro fibrillation with dependency on their chemical structure. These results demonstrate the simplicity and the synthetic potential of the oxime conjugation for the preparation of peptide amphiphiles with improved self-assembling capabilities
dc.description.sponsorshipThis work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [CTQ2014-59646-R, SAF2017-89890-R], the Xunta de Galicia (ED431G/09, ED431C 2017/25 and 2016-AD031) and the ERDF. I.I. thanks the Spanish AEI for a Juan de la Cierva -Formación fellowship (FJCI-2017-31795). J.M. received a Ramón y Cajal (RYC-2013-13784), an ERC Starting Investigator Grant (DYNAP-677786) and a Young Investigator Grant from the Human Frontier Science Research Program (RGY0066/2017)
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.rights© 2018 Royal Society of Chemistry
dc.titleSelf-Assembled Micro-Fibres by Oxime Connection of Linear Peptide Amphiphiles
dc.typejournal article
dc.identifier.doi10.1039/C8OB02243G
dc.relation.publisherversionhttps://doi.org/10.1039/C8OB02243G
dc.type.hasVersionAM
dc.identifier.essn1477-0539
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/677786
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-89890-R/ES/PEPTIDOS HIBRIDOS PARA EL TRANSPORTE SELECTIVO Y ENTREGA DE PROTEINAS TERAPEUTICAS
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2014-59646-R/ES/NUEVOS DISEÑOS CON CONTROL TOPOLOGICO DE PEPTIDOS PENETRANTES EN CELULAS
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2013-13784/ES


Ficheiros no ítem

application/pdf
Nome: 2018_organicbiomolec_booth_selfassembled.pdf
Tamaño: 1.171 Mb
Formato: PDF


application/pdf
Nome: 2018_organicbiomolec_booth_selfassembled_supplinfo.pdf
Tamaño: 9.744 Mb
Formato: PDF


Thumbnail

Este ítem aparece na(s) seguinte(s) colección(s)

Mostrar o rexistro simple do ítem






Recolectores:Enlaces de interese:
Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contacto | Suxestións