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dc.contributor.advisorSánchez Barreiro, Alejandro
dc.contributor.advisorDiebold Luque, Yolanda
dc.contributor.authorÁlvarez Trabado, Jesús
dc.date.accessioned2018-12-27T12:59:26Z
dc.date.available2018-12-27T12:59:26Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10347/18034
dc.description.abstractIn this thesis, we developed a new nanoparticle-based therapeutic strategy for the treatment of ocular surface diseases. Two types of sorbitan ester nanoparticles (SENS) for topical ocular administration, including a cationic nanosystem and its hyaluronic acid-coated version, were developed and optimized. Both types of nanoparticles were physicochemically characterized and evaluated in terms of biocompatibility, targeting ability and therapeutic efficacy. Moreover, the therapeutic potential of developed nanoparticles to treat dry eye disease was demonstrated in an in vivo disease model. Overall, results obtained in this work confirm the suitability and clinical potential of SENS as drug delivery systems for the topical treatment of ocular surface pathologies. Particularly, the beneficial effects of HA-coating on the physicochemical and biopharmaceutical properties, and therapeutic efficacy of nanoparticles were elucidated.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNanoparticles
dc.subjectOcular
dc.subjectHyaluronic acid
dc.titleSorbitan ester nanoparticles as a novel tool for the treatment of ocular surface diseases
dc.typeinfo:eu-repo/semantics/doctoralThesis
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)
dc.contributor.affiliationUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde
dc.contributor.affiliationUniversidade de Santiago de Compostela. Programa de Doutoramento en Investigación e Desenvolvemento de Medicamentos


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