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dc.contributor.authorPazos Chantrero, Elena
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.date.accessioned2019-02-01T12:14:45Z
dc.date.available2019-02-01T12:14:45Z
dc.date.issued2014
dc.identifier.citationPazos, E. and Vázquez, M. E. (2014), Advances in lanthanide‐based luminescent peptide probes for monitoring the activity of kinase and phosphatase. Biotechnology Journal, 9: 241-252. doi:10.1002/biot.201300203
dc.identifier.issn1860-6768
dc.identifier.urihttp://hdl.handle.net/10347/18203
dc.descriptionThis is the peer reviewed version of the following article: Pazos, E. and Vázquez, M. E. (2014), Advances in lanthanide‐based luminescent peptide probes for monitoring the activity of kinase and phosphatase. Biotechnology Journal, 9: 241-252. doi:10.1002/biot.201300203, which has been published in final form at https://doi.org/10.1002/biot.201300203. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
dc.description.abstractSignaling pathways based on protein phosphorylation and dephosphorylation play critical roles in the orchestration of complex biochemical events and form the core of most signaling pathways in cells (i.e. cell cycle regulation, cell motility, apoptosis, etc.). The understanding of these complex signaling networks is based largely on the biochemical study of their components, i.e. kinases and phosphatases. The development of luminescent sensors for monitoring kinase and phosphatase activity is therefore an active field of research. Examples in the literature usually rely on the modulation of the fluorescence emission of organic fluorophores. However, given the exceptional photophysical properties of lanthanide ions, there is an increased interest in their application as emissive species for monitoring kinase and phosphatase activity. This review summarizes the advances in the development of lanthanide‐based luminescent peptide sensors as tools for the study of kinases and phosphatases and provides a critical description of current examples and synthetic approaches to understand these lanthanide‐based luminescent peptide sensors
dc.description.sponsorshipWe thank the support of the Spanish government’s grantsSAF2010-20822-C02, CTQ2012-31341, CTQ2009-14431,SAF2007-61015 and the Xunta de Galicia INCITE09 209 084PR, GRC2010/12, PGIDIT08CSA-047209PR. E.P.thanks the Fundación Barrié de la Maza for her postdoc-toral fellowship
dc.language.isoeng
dc.publisherWiley
dc.rights© 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
dc.subjectFluorescent assays
dc.subjectKinase sensing
dc.subjectLuminescence
dc.subjectPhosphatase sensing
dc.subjectSensors
dc.titleAdvances in lanthanide‐based luminescent peptide probes for monitoring the activity of kinase and phosphatase
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1002/biot.201300203
dc.relation.publisherversionhttps://doi.org/10.1002/biot.201300203
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.e-issn1860-7314
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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