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dc.contributor.advisorAlonso Fernández, María José
dc.contributor.advisorCsaba, Noémi Stefania
dc.contributor.authorTeijeiro Valiño, Carmen
dc.date.accessioned2019-02-25T11:51:24Z
dc.date.available2019-02-25T11:51:24Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10347/18300
dc.description.abstractThe work reported in this thesis, has been oriented to the design of multifunctional nanocapsules for the administration of antitumoral drugs. These systems are based on the use of hyaluronic acid or modified hyaluronic. These materials provide nanocapsules with specific affinity for cancer cells through specific cancer cell receptors, respectively. The physico-chemical characterization showed these prototypes present favourable properties for the administration of antitumoral drugs. Additionally, the study of in vivo fate in a cancer animal model showed a marked increase of drug accumulation in tumour tissue, especially for ligand modified nanocapsules, which have achieved also an improvement in therapeutic efficacy.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectfármacos antitumorales
dc.subjectnanocápsulas
dc.subjectácido hialurónico
dc.subject.classificationMaterias::Investigación::23 Química::2390 Química farmacéutica::239001 Diseño. Síntesis y estudio nuevos fármacos
dc.subject.classificationMaterias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320806 Quimioterapia
dc.titleNanocápsulas multifuncionales para la liberación selectiva de fármacos antitumorales
dc.typeinfo:eu-repo/semantics/doctoralThesis
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Facultade de Farmacia
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica


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