Ruthenation of Non‐stacked Guanines in DNA G‐Quadruplex Structures: Enhancement of c‐MYC Expression
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| Title: | Ruthenation of Non‐stacked Guanines in DNA G‐Quadruplex Structures: Enhancement of c‐MYC Expression |
| Author: | Rodríguez Villar, Jéssica Mosquera Mosquera, Jesús Rodríguez Couceiro, José Vázquez Sentís, Marco Eugenio Mascareñas Cid, José Luis |
| Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Subject: | Bioinorganic chemistry | DNA damage | Metalation | Photochemistry | Ruthenium | |
| Date of Issue: | 2016 |
| Publisher: | Wiley |
| Citation: | J. Rodríguez, J. Mosquera, J. R. Couceiro, M. E. Vázquez, J. L. Mascareñas, Angew. Chem. Int. Ed. 2016, 55, 15615 |
| Abstract: | Guanine quadruplexes (GQs) are compact four‐stranded DNA structures that play a key role in the control of a variety of biological processes, including gene transcription. Bulky ruthenium complexes featuring a bipyridine, a terpyridine, and one exchangeable ligand ([Ru(terpy)(bpy)X]n+) are able to metalate exposed guanines present in the GQ of the c‐MYC promoter region that are not involved in quadruplex base pairing. qRT‐PCR and western‐blot experiments indicated that the complexes promote a remarkable increase in the expression of this oncogene. We also show that exchangeable thioether ligands (X=RSR′, Met) allow regulation of the metalating activity of the complex with visible light |
| Publisher version: | https://doi.org/10.1002/anie.201607965 |
| URI: | http://hdl.handle.net/10347/18334 |
| DOI: | 10.1002/anie.201607965 |
| ISSN: | 1433-7851 |
| E-ISSN: | 1521-3773 |
| Rights: | © 2016 Die Autoren. Verçffentlicht von Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This article is licensed under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) |
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Except where otherwise noted, this item's license is described as © 2016 Die Autoren. Verçffentlicht von Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This article is licensed under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)