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dc.contributor.authorRodríguez Villar, Jéssica
dc.contributor.authorMosquera Mosquera, Jesús
dc.contributor.authorRodríguez Couceiro, José
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2019-03-12T07:41:00Z
dc.date.available2019-03-12T07:41:00Z
dc.date.issued2016
dc.identifier.citationJ. Rodríguez, J. Mosquera, J. R. Couceiro, M. E. Vázquez, J. L. Mascareñas, Angew. Chem. Int. Ed. 2016, 55, 15615
dc.identifier.issn1433-7851
dc.identifier.urihttp://hdl.handle.net/10347/18334
dc.description.abstractGuanine quadruplexes (GQs) are compact four‐stranded DNA structures that play a key role in the control of a variety of biological processes, including gene transcription. Bulky ruthenium complexes featuring a bipyridine, a terpyridine, and one exchangeable ligand ([Ru(terpy)(bpy)X]n+) are able to metalate exposed guanines present in the GQ of the c‐MYC promoter region that are not involved in quadruplex base pairing. qRT‐PCR and western‐blot experiments indicated that the complexes promote a remarkable increase in the expression of this oncogene. We also show that exchangeable thioether ligands (X=RSR′, Met) allow regulation of the metalating activity of the complex with visible light
dc.description.sponsorshipWe thank the support by the Spanish grants SAF2013‐41943‐R, CTQ2015‐70698‐R, and CTQ2013‐49317‐EXP, the Xunta de Galicia GRC2013‐041, the ERDF, and the European Research Council (Advanced Grant No. 340055). Support of COST Action CM1105, COST CM1306 and the orfeo‐cinqa network are also kindly acknowledged. J.R. thanks the Xunta de Galicia for a Ph.D. fellowship
dc.language.isoeng
dc.publisherWiley
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.rights© 2016 Die Autoren. Verçffentlicht von Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This article is licensed under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBioinorganic chemistry
dc.subjectDNA damage
dc.subjectMetalation
dc.subjectPhotochemistry
dc.subjectRuthenium
dc.titleRuthenation of Non‐stacked Guanines in DNA G‐Quadruplex Structures: Enhancement of c‐MYC Expression
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1002/anie.201607965
dc.relation.publisherversionhttps://doi.org/10.1002/anie.201607965
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1521-3773
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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© 2016 Die Autoren. Verçffentlicht von Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This article is licensed under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Except where otherwise noted, this item's license is described as  © 2016 Die Autoren. Verçffentlicht von Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This article is licensed under a Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)





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