Metal-catalyzed uncaging of DNA-binding agents in living cells
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Título: | Metal-catalyzed uncaging of DNA-binding agents in living cells |
Autor/a: | Sánchez López, Mateo Isidro Penas Tallón, Cristina Vázquez Sentís, Marco Eugenio Mascareñas Cid, José Luis |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Data: | 2014 |
Editor: | Royal Society of Chemistry |
Cita bibliográfica: | Sánchez, M., Penas, C., Vázquez, M., & Mascareñas, J. (2014). Metal-catalyzed uncaging of DNA-binding agents in living cells. Chem. Sci., 5(5), 1901-1907. doi: 10.1039/c3sc53317d |
Resumo: | Attachment of alloc protecting groups to the amidine units of fluorogenic DNA-binding bisbenzamidines or to the amino groups of ethidium bromide leads to a significant reduction of their DNA affinity. More importantly, the active DNA-binding species can be readily regenerated by treatment with ruthenium catalysts in aqueous conditions, even in cell cultures. The catalytic chemical uncaging can be easily monitored by fluorescence microscopy, because the protected products display both different emission properties and cell distribution to the parent compounds |
Versión do editor: | https://doi.org/10.1039/C3SC53317D |
URI: | http://hdl.handle.net/10347/18336 |
DOI: | 10.1039/C3SC53317D |
E-ISSN: | 2041-6539 |
Dereitos: | © The Royal Society of Chemistry 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited |
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