The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments
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Título: | The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments
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Autor/a: | Rodríguez Villar, Jéssica
Mosquera Mosquera, Jesús
Rodríguez Couceiro, José
Vázquez Sentís, Marco Eugenio
Mascareñas Cid, José Luis
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Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica
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Data: | 2015
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Editor: | Royal Society of Chemistry
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Cita bibliográfica: | Rodríguez, J., Mosquera, J., Couceiro, J., Vázquez, M., & Mascareñas, J. (2015). The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments. Chemical Science, 6(8), 4767-4771. doi: 10.1039/c5sc01415h
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Resumo: | We report the development of chimeric DNA binding peptides comprising a DNA binding fragment of natural transcription factors (the basic region of a bZIP protein or a monomeric zinc finger module) and an AT-Hook peptide motif. The resulting peptide conjugates display high DNA affinity and excellent sequence selectivity. Furthermore, the AT-Hook motif also favors the cell internalization of the conjugates |
Versión do editor: | https://doi.org/10.1039/C5SC01415H |
URI: | http://hdl.handle.net/10347/18337
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DOI: | 10.1039/c5sc01415h |
E-ISSN: | 2041-6539
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Dereitos: | © The Royal Society of Chemistry 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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