| dc.contributor.author | Rodríguez Villar, Jéssica |
| dc.contributor.author | Mosquera Mosquera, Jesús |
| dc.contributor.author | Rodríguez Couceiro, José |
| dc.contributor.author | Vázquez Sentís, Marco Eugenio |
| dc.contributor.author | Mascareñas Cid, José Luis |
| dc.date.accessioned | 2019-03-12T07:53:08Z |
| dc.date.available | 2019-03-12T07:53:08Z |
| dc.date.issued | 2015 |
| dc.identifier.citation | Rodríguez, J., Mosquera, J., Couceiro, J., Vázquez, M., & Mascareñas, J. (2015). The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments. Chemical Science, 6(8), 4767-4771. doi: 10.1039/c5sc01415h |
| dc.identifier.uri | http://hdl.handle.net/10347/18337 |
| dc.description.abstract | We report the development of chimeric DNA binding peptides comprising a DNA binding fragment of natural transcription factors (the basic region of a bZIP protein or a monomeric zinc finger module) and an AT-Hook peptide motif. The resulting peptide conjugates display high DNA affinity and excellent sequence selectivity. Furthermore, the AT-Hook motif also favors the cell internalization of the conjugates |
| dc.description.sponsorship | We are thankful for the support given by the Spanish grants SAF2013-41943 R, CTQ2012-31341, and CTQ2013-49317-EXP; the Xunta de Galicia GRC2013-041, the ERDF and the European Research Council (Advanced Grant 340055). Support of COST Action CM1105 and the Orfeo-Cinqa also is kindly acknowledged. J.R. thanks the Xunta de Galicia for her PhD fellowship |
| dc.language.iso | eng |
| dc.publisher | Royal Society of Chemistry |
| dc.relation | info:eu-repo/grantAgreement/EC/FP7/340055 |
| dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-49317/ES/EXPLORACION DE TERAPIAS ANTITUMORALES ALTERNATIVAS DIRIGIDAS A LAS MITOCONDRIAS |
| dc.rights | © The Royal Society of Chemistry 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
| dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ |
| dc.title | The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments |
| dc.type | info:eu-repo/semantics/article |
| dc.identifier.DOI | 10.1039/c5sc01415h |
| dc.relation.publisherversion | https://doi.org/10.1039/C5SC01415H |
| dc.type.version | info:eu-repo/semantics/publishedVersion |
| dc.identifier.e-issn | 2041-6539 |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess |
| dc.contributor.affiliation | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares |
| dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| dc.description.peerreviewed | SI |
