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dc.contributor.authorRodríguez Villar, Jéssica
dc.contributor.authorMosquera Mosquera, Jesús
dc.contributor.authorRodríguez Couceiro, José
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2019-03-12T07:53:08Z
dc.date.available2019-03-12T07:53:08Z
dc.date.issued2015
dc.identifier.citationRodríguez, J., Mosquera, J., Couceiro, J., Vázquez, M., & Mascareñas, J. (2015). The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments. Chemical Science, 6(8), 4767-4771. doi: 10.1039/c5sc01415h
dc.identifier.urihttp://hdl.handle.net/10347/18337
dc.description.abstractWe report the development of chimeric DNA binding peptides comprising a DNA binding fragment of natural transcription factors (the basic region of a bZIP protein or a monomeric zinc finger module) and an AT-Hook peptide motif. The resulting peptide conjugates display high DNA affinity and excellent sequence selectivity. Furthermore, the AT-Hook motif also favors the cell internalization of the conjugates
dc.description.sponsorshipWe are thankful for the support given by the Spanish grants SAF2013-41943 R, CTQ2012-31341, and CTQ2013-49317-EXP; the Xunta de Galicia GRC2013-041, the ERDF and the European Research Council (Advanced Grant 340055). Support of COST Action CM1105 and the Orfeo-Cinqa also is kindly acknowledged. J.R. thanks the Xunta de Galicia for her PhD fellowship
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-49317/ES/EXPLORACION DE TERAPIAS ANTITUMORALES ALTERNATIVAS DIRIGIDAS A LAS MITOCONDRIAS
dc.rights© The Royal Society of Chemistry 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.titleThe AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1039/c5sc01415h
dc.relation.publisherversionhttps://doi.org/10.1039/C5SC01415H
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn2041-6539
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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© The Royal Society of Chemistry 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Except where otherwise noted, this item's license is described as  © The Royal Society of Chemistry 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited





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