Synthetic nanocarriers for the delivery of polynucleotides to the eye
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Título: | Synthetic nanocarriers for the delivery of polynucleotides to the eye |
Autor/a: | Mendes Saraiva, Sofia Castro López, Vanessa Pañeda Vázquez-Prada, Covadonga Alonso Fernández, María José |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica |
Palabras chave: | Polynucleotides | Nanocarriers | Ocular polynucleotide delivery | Anterior segment | Posterior segment | Eye | |
Data: | 2017-05-30 |
Editor: | Elsevier |
Cita bibliográfica: | Saraiva, S., Castro-López, V., Pañeda, C., & Alonso, M. (2017). Synthetic nanocarriers for the delivery of polynucleotides to the eye. European Journal Of Pharmaceutical Sciences, 103, 5-18. doi: 10.1016/j.ejps.2017.03.001 |
Resumo: | This review is a comprehensive analysis of the progress made so far on the delivery of polynucleotide-based therapeutics to the eye, using synthetic nanocarriers. Attention has been addressed to the capacity of different nanocarriers for the specific delivery of polynucleotides to both, the anterior and posterior segments of the eye, with emphasis on their ability to (i) improve the transport of polynucleotides across the different eye barriers; (ii) promote their intracellular penetration into the target cells; (iii) protect them against degradation and, (iv) deliver them in a long-term fashion way. Overall, the conclusion is that despite the advantages that nanotechnology may offer to the area of ocular polynucleotide-based therapies (especially AS-ODN and siRNA delivery), the knowledge disclosed so far is still limited. This fact underlines the necessity of more fundamental and product-oriented research for making the way of the said nanotherapies towards clinical translation |
Descrición: | This is the accepted manuscript of the following article: Saraiva, S., Castro-López, V., Pañeda, C., & Alonso, M. (2017). Synthetic nanocarriers for the delivery of polynucleotides to the eye. European Journal Of Pharmaceutical Sciences, 103, 5-18. doi: 10.1016/j.ejps.2017.03.001 |
Versión do editor: | https://doi.org/10.1016/j.ejps.2017.03.001 |
URI: | http://hdl.handle.net/10347/18359 |
DOI: | 10.1016/j.ejps.2017.03.001 |
ISSN: | 0928-0987 |
Dereitos: | © 2017 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Coleccións
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- CIMUS-Artigos [249]
- FTF-Artigos [274]