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dc.contributor.authorCastro Varela, Gabriela
dc.contributor.authorRodríguez Pereiro, Isaac
dc.contributor.authorRamil Criado, María
dc.contributor.authorCela Torrijos, Rafael
dc.date.accessioned2019-03-20T07:44:00Z
dc.date.available2021-02-27T02:00:10Z
dc.date.issued2019
dc.identifier.citationCastro, G., Rodríguez, I., Ramil, M., & Cela, R. (2019). Selective determination of sartan drugs in environmental water samples by mixed-mode solid-phase extraction and liquid chromatography tandem mass spectrometry. Chemosphere, 224, 562-571. doi: 10.1016/j.chemosphere.2019.02.137
dc.identifier.issn0045-6535
dc.identifier.urihttp://hdl.handle.net/10347/18412
dc.descriptionThis is the accepted manuscript of the following article: Castro, G., Rodríguez, I., Ramil, M., & Cela, R. (2019). Selective determination of sartan drugs in environmental water samples by mixed-mode solid-phase extraction and liquid chromatography tandem mass spectrometry. Chemosphere, 224, 562-571. doi: 10.1016/j.chemosphere.2019.02.137
dc.description.abstractHerein, a method for the simultaneous determination of the currently prescribed sartan drugs (eprosartan, EPR; olmesartan, OLM; losartan, LOS; candesartan, CAN; telmisartan, TEL; irbesartan, IRB; and valsartan, VAL), and the biodegradation product valsartan acid (VALA), in water samples (raw and treated wastewater, river and tap water) was developed. Solid-phase extraction (SPE) and ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS) were employed as concentration and determination techniques, respectively. Different sorbents and elution solvents were tested for sample preparation. Under optimized conditions, samples at neutral pH (6–8 units) were concentrated using mixed-mode (reversed-phase and anionic exchange) cartridges. Thereafter, the sorbent was washed with 5 mL of a methanol: water (1:1) solution, dried under a nitrogen stream and compounds were eluted with 2 mL of methanol: NH3 (98:2). The accuracy of the method (accounting for SPE efficiency and matrix effects during electrospray ionization) was investigated using solvent-based calibration standards. Global recoveries, obtained for different water matrices (tap, river, treated and raw wastewater), ranged from 82% to 134%, with standard deviations between 2 and 18%. LOQs varied from 2 to 50 ng L−1. Analysis of un-spiked samples confirmed: (1) the incomplete removal of sartans at sewage treatment plants (STPs), (2) the formation of VALA during municipal water treatment, and (3) the presence of VALA in the processed tap water samples. Additional findings of the current study are the detection of hydroxylated derivatives of the sartan drugs IRB and LOS in wastewater, and the E-Z isomerization of EPR in environmental water samples
dc.description.sponsorshipThis study was supported by Xunta de Galicia (grant GRC-ED431C 2017/36), and the Spanish Government (grant CTQ2015-68660-P)
dc.language.isoeng
dc.publisherElsevier
dc.rights© Elsevier 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (https://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSartans
dc.subjectValsartan acid
dc.subjectMixed-mode solid-phase extraction
dc.subjectLiquid chromatography tandem mass spectrometry
dc.subjectWater analysis
dc.titleSelective determination of sartan drugs in environmental water samples by mixed-mode solid-phase extraction and liquid chromatography tandem mass spectrometry
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1016/j.chemosphere.2019.02.137
dc.relation.publisherversionhttps://doi.org/10.1016/j.chemosphere.2019.02.137
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía
dc.contributor.affiliationUniversidade de Santiago de Compostela. Instituto de Investigación e Análises Alimentarias
dc.description.peerreviewedSI


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© Elsevier 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Except where otherwise noted, this item's license is described as  © Elsevier 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (https://creativecommons.org/licenses/by-nc-nd/4.0/)





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