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dc.contributor.authorDestito, Paolo
dc.contributor.authorSousa Castillo, Ana
dc.contributor.authorRodríguez Couceiro, José
dc.contributor.authorLópez García, Fernando
dc.contributor.authorCorrea Duarte, Miguel Ángel
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2019-03-21T14:27:04Z
dc.date.available2019-03-21T14:27:04Z
dc.date.issued2019
dc.identifier.citationDestito, P., Sousa-Castillo, A., Couceiro, J., López, F., Correa-Duarte, M., & Mascareñas, J. (2019). Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media. Chemical Science, 10(9), 2598-2603. doi: 10.1039/c8sc04390f
dc.identifier.issn2041-6539
dc.identifier.urihttp://hdl.handle.net/10347/18462
dc.description.abstractWe describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles and their use as Pd-nanoreactors in aqueous media. These palladium-equipped capsules can be used to promote the uncaging of propargyl-protected phenols, as well as Suzuki–Miyaura cross-coupling, in water and at physiologically compatible temperatures. Importantly, the depropargylation reaction can be accomplished in a bioorthogonal manner in the presence of relatively high concentrations of biomolecular components and even in the presence of mammalian cells
dc.description.sponsorshipThis work has received financial support from Spanish grants (SAF2016-76689-R, CTQ2017-84767-P, CTM2014-58481-R, CTM2017-84050-R and Orfeo-Cinqa network CTQ2016-81797- REDC), the Consellería de Cultura, Educación e Ordenación Universitaria (2015-CP082, ED431C/2017119 and Centro Singular de Investigación de Galicia accreditation 2016–2019, ED431G/09), the European Union (European Regional Development Fund-ERDF corresponding to the multiannual financial framework 2014–2020), and the European Research Council (Advanced Grant No. 340055)
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-81797/ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-76689-R/ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017-84767-P/ES/METODOS SINTETICOS EFICIENTES BASADOS EN CATALISIS METALICA. DESARROLLOS ENANTIOSELECTIVOS Y ACCESO A MOLECULAS BIOACTIVAS Y/O DE ALTO INTERES SINTETICO
dc.rights© The Royal Society of Chemistry 2019. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.titleHollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1039/c8sc04390f
dc.relation.publisherversionhttps://doi.org/10.1039/C8SC04390F
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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© The Royal Society of Chemistry 2019. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence
Except where otherwise noted, this item's license is described as  © The Royal Society of Chemistry 2019. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence





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