In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains
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| Title: | In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains |
| Author: | Sánchez López, Mateo Isidro Martínez Costas, José Manuel González García, Francisco Álvarez Bermúdez, María José Vázquez Sentís, Marco Eugenio Mascareñas Cid, José Luis |
| Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Bioquímica e Bioloxía Molecular Universidade de Santiago de Compostela. Departamento de Fisioloxía Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Date of Issue: | 2012 |
| Publisher: | American Chemical Society |
| Citation: | Sánchez, M., Martínez-Costas, J., Gonzalez, F., Bermudez, M., Vázquez, M., & Mascareñas, J. (2012). In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains. ACS Chemical Biology, 7(7), 1276-1280. doi: 10.1021/cb300100r |
| Abstract: | Chemical derivatization of nucleic stains such as ethidium bromide or DAPI with tailored, photoresponsive caging groups, allows for “on demand” spatiotemporal control of their in vivo nucleic acid binding, as well as for improving their cellular uptake. This effect was particularly noteworthy for a nitro-veratryloxycarbonyl-caged derivative of ethidium bromide that, in contrast with the parent stain, is effectively internalized into living cells. The activation strategy works in light-accessible, therapeutically relevant settings, such as human retinas, and can even be applied for the release of active compounds in the eyes of living mice |
| Description: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in
ACS Chemical Biology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: https://pubs.acs.org/doi/10.1021/cb300100r |
| Publisher version: | https://doi.org/10.1021/cb300100r |
| URI: | http://hdl.handle.net/10347/18472 |
| DOI: | 10.1021/cb300100r |
| ISSN: | 1554-8929 |
| E-ISSN: | 1554-8937 |
| Rights: | © 2012 American Chemical Society |
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