MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria
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Título: | MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria |
Autor/a: | Sánchez López, Mateo Isidro Martínez Costas, José Manuel Mascareñas Cid, José Luis Vázquez Sentís, Marco Eugenio |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Bioquímica e Bioloxía Molecular Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Data: | 2014 |
Editor: | American Chemical Society |
Cita bibliográfica: | Sánchez, M., Martínez-Costas, J., Mascareñas, J., & Vázquez, M. (2014). MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria. ACS Chemical Biology, 9(12), 2742-2747. doi: 10.1021/cb500552f |
Resumo: | We report the discovery of a fluorogenic dye, N1,N3-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high resistance to photobleaching. Additionally, we show that a biotin-labeled MitoBlue derivative can be used as a handle for the delivery of streptavidin-tagged species to the mitochondria |
Versión do editor: | https://doi.org/10.1021/cb500552f |
URI: | http://hdl.handle.net/10347/18473 |
DOI: | 10.1021/cb500552f |
ISSN: | 1554-8929 |
E-ISSN: | 1554-8937 |
Dereitos: | © 2014 American Chemical Society. This is an open access article published under an ACS AuthorChoice License (https://pubs.acs.org/page/policy/authorchoice_termsofuse.html), which permits copying and redistribution of the article or any adaptations for non-commercial purposes |
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