Palladium-Catalyzed Conjugate Addition of Terminal Alkynes to Enones
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| Title: | Palladium-Catalyzed Conjugate Addition of Terminal Alkynes to Enones |
| Author: | Villarino Palmaz, Lara García Fandiño, Rebeca López García, Fernando Mascareñas Cid, José Luis |
| Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Date of Issue: | 2012 |
| Publisher: | American Chemical Society |
| Citation: | Villarino, L., García-Fandiño, R., López, F., & Mascareñas, J. (2012). Palladium-Catalyzed Conjugate Addition of Terminal Alkynes to Enones. Org. Lett., 14, 12, 2996-2999. DOI: 10.1021/ol300988n |
| Abstract: | A practical protocol for the hydroalkynylation of enones using Pd catalysis is reported. The reaction proceeds efficiently with a variety of alkynes as well as with several cyclic and acyclic enones, providing synthetically relevant β-alkynyl ketones in good to excellent yields |
| Description: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Chemical Biology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: https://pubs.acs.org/doi/10.1021/ol300988n |
| Publisher version: | https://doi.org/10.1021/ol300988n |
| URI: | http://hdl.handle.net/10347/18477 |
| DOI: | 10.1021/ol300988n |
| ISSN: | 1523-7060 |
| E-ISSN: | 1523-7052 |
| Rights: | © 2012 American Chemical Society |
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