Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers
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| Title: | Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers |
| Author: | Jiménez Balsa, Adrián Pazos Chantrero, Elena Martínez Albardonedo, Borja Mascareñas Cid, José Luis Vázquez Sentís, Marco Eugenio |
| Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Subject: | Amino acids | DNA recognition | Peptides | Photochemistry | Protein design | |
| Date of Issue: | 2012 |
| Publisher: | Wiley |
| Citation: | Jiménez‐Balsa, A., Pazos, E., Martínez‐Albardonedo, B., Mascareñas, J. L. and Vázquez, M. E. (2012), Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers. Angew. Chem. Int. Ed., 51: 8825-8829. doi:10.1002/anie.201201627 |
| Abstract: | Appending negatively charged Glu8 tails to a peptide dimer derived from the GCN4 transcription factor leads to an effective suppression of its DNA binding. The specific DNA recognition can be restored by irradiation with UV light by using a photolabile linker between the acidic tail and the DNA binding peptide |
| Description: | This is the peer reviewed version of the following article: Jiménez‐Balsa, A. , Pazos, E. , Martínez‐Albardonedo, B. , Mascareñas, J. L. and Vázquez, M. E. (2012), Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers. Angew. Chem. Int. Ed., 51: 8825-8829, which has been published in final form at https://doi.org/10.1002/anie.201201627. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions |
| Publisher version: | https://doi.org/10.1002/anie.201201627 |
| URI: | http://hdl.handle.net/10347/18482 |
| DOI: | 10.1002/anie.201201627 |
| ISSN: | 1433-7851 |
| E-ISSN: | 1521-3773 |
| Rights: | © 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions |
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