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dc.contributor.authorPenas Tallón, Cristina
dc.contributor.authorSánchez López, Mateo Isidro
dc.contributor.authorGuerra Varela, Jorge
dc.contributor.authorSánchez Piñón, Laura
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2019-03-27T15:01:44Z
dc.date.available2019-03-27T15:01:44Z
dc.date.issued2016
dc.identifier.citationC. Penas, M. I. Sánchez, J. Guerra-Varela, L. Sanchez, M. E. Vázquez, J. L. Mascareñas (2016). Light‐Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid‐Binding Agents: Studies in Vitro and in Zebrafish Embryos. ChemBioChem, 17, 37-41. DOI: 10.1002/cbic.201500455
dc.identifier.urihttp://hdl.handle.net/10347/18485
dc.descriptionThis is the peer reviewed version of the following article: C. Penas, M. I. Sánchez, J. Guerra-Varela, L. Sanchez, M. E. Vázquez, J. L. Mascareñas, ChemBioChem 2016, 17, 37-41, which has been published in final form at https://doi.org/10.1002/cbic.201500455. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
dc.description.abstractWe synthesized octa‐arginine conjugates of DNA‐binding agents (bisbenzamidine, acridine and Thiazole Orange) and demonstrated that their DNA binding and cell internalization can be inhibited by appending a (negatively charged) oligoglutamic tail through a photolabile linker. UV irradiation released the parent conjugates, thus restoring cell internalization and biological activity. Assays with zebrafish embryos demonstrates the potential of this prodrug strategy for controlling in vivo cytotoxicity
dc.description.sponsorshipWe are thankful for the support given by the Spanish grants SAF2013–41943‐R, CTQ2012–31341 and CTQ2013–49317‐EXP, the Xunta de Galicia GRC2013–041, the ERDF and the European Research Council (Advanced Grant 340055). C.P. and M.I.S. thank the Spanish MCINN for their PhD fellowships
dc.language.isoeng
dc.publisherWiley
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.rights© 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
dc.subjectDNA recognition
dc.subjectCaged compounds
dc.subjectFluorescent probes
dc.subjectPeptides
dc.subjectSupramolecular chemistry
dc.titleLight-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1002/cbic.201500455
dc.relation.publisherversionhttps://doi.org/10.1002/cbic.201500455
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.e-issn1439-7633
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física
dc.description.peerreviewedSI


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