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dc.contributor.authorRodríguez Villar, Jéssica
dc.contributor.authorMosquera Mosquera, Jesús
dc.contributor.authorVázquez Vázquez, Olalla
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2019-03-27T15:47:31Z
dc.date.available2019-03-27T15:47:31Z
dc.date.issued2014
dc.identifier.citationRodríguez, J., Mosquera, J., Vázquez, O., Vázquez, M., & Mascareñas, J. (2014). The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative. Chem. Commun.,50, 2258-2260. doi: 10.1039/c3cc47599a
dc.identifier.issn1359-7345
dc.identifier.urihttp://hdl.handle.net/10347/18487
dc.description.abstractWe report the selective modification of cysteine residues engineered in peptides that have two additional cysteine residues as part of a Cys2His2 zinc finger motif. The chemoselective modification is achieved, thanks to the protecting effect exerted by the zinc cation upon coordination with the native cysteines and histidines of the zinc-finger fold. The strategy allows a straightforward synthesis of DNA binding zinc finger constructs
dc.description.sponsorshipWe acknowledge the support from the Spanish grants SAF2010-20822-C02, CTQ2009-14431/BQU, CSD2007-00006, the Xunta de Galicia GRC2010/12, GRC2013-041 and INCITE09 209 084PR. J. R. thanks the Fundación Gil Dávila and the Xunta de Galicia and J. M. the Spanish MCINN for their PhD fellowships
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.rights© The Royal Society of Chemistry 2014
dc.titleThe ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative
dc.typejournal article
dc.identifier.doi10.1039/C3CC47599A
dc.relation.publisherversionhttps://doi.org/10.1039/C3CC47599A
dc.type.hasVersionAM
dc.identifier.essn1364-548X
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN/Plan Nacional de I+D+i 2008-2011/SAF2010-20822-C02/ES/DISEÑO Y DESARROLLO DE PROCESOS ENANTIOSELECTIVOS CATALIZADOS POR METALES DE TRANSICION PARA LA OBTENCION DE ESTRUCTURAS POLICICLICAS BIOLOGICAMENTE RELAVANTES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MEC/Plan Nacional de I+D+i 2004-2007/CSD2007-00006/ES/Desarrollo de entidades organometálicas para reacciones de funcionalización selectiva en moléculas orgánicas


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