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dc.contributor.author | Rodríguez Villar, Jéssica |
dc.contributor.author | Mosquera Mosquera, Jesús |
dc.contributor.author | Vázquez Vázquez, Olalla |
dc.contributor.author | Vázquez Sentís, Marco Eugenio |
dc.contributor.author | Mascareñas Cid, José Luis |
dc.date.accessioned | 2019-03-27T15:47:31Z |
dc.date.available | 2019-03-27T15:47:31Z |
dc.date.issued | 2014 |
dc.identifier.citation | Rodríguez, J., Mosquera, J., Vázquez, O., Vázquez, M., & Mascareñas, J. (2014). The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative. Chem. Commun.,50, 2258-2260. doi: 10.1039/c3cc47599a |
dc.identifier.issn | 1359-7345 |
dc.identifier.uri | http://hdl.handle.net/10347/18487 |
dc.description.abstract | We report the selective modification of cysteine residues engineered in peptides that have two additional cysteine residues as part of a Cys2His2 zinc finger motif. The chemoselective modification is achieved, thanks to the protecting effect exerted by the zinc cation upon coordination with the native cysteines and histidines of the zinc-finger fold. The strategy allows a straightforward synthesis of DNA binding zinc finger constructs |
dc.description.sponsorship | We acknowledge the support from the Spanish grants SAF2010-20822-C02, CTQ2009-14431/BQU, CSD2007-00006, the Xunta de Galicia GRC2010/12, GRC2013-041 and INCITE09 209 084PR. J. R. thanks the Fundación Gil Dávila and the Xunta de Galicia and J. M. the Spanish MCINN for their PhD fellowships |
dc.language.iso | eng |
dc.publisher | Royal Society of Chemistry |
dc.rights | © The Royal Society of Chemistry 2014 |
dc.title | The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative |
dc.type | journal article |
dc.identifier.doi | 10.1039/C3CC47599A |
dc.relation.publisherversion | https://doi.org/10.1039/C3CC47599A |
dc.type.hasVersion | AM |
dc.identifier.essn | 1364-548X |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
dc.description.peerreviewed | SI |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN/Plan Nacional de I+D+i 2008-2011/SAF2010-20822-C02/ES/DISEÑO Y DESARROLLO DE PROCESOS ENANTIOSELECTIVOS CATALIZADOS POR METALES DE TRANSICION PARA LA OBTENCION DE ESTRUCTURAS POLICICLICAS BIOLOGICAMENTE RELAVANTES |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC/Plan Nacional de I+D+i 2004-2007/CSD2007-00006/ES/Desarrollo de entidades organometálicas para reacciones de funcionalización selectiva en moléculas orgánicas |
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