Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasis
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http://hdl.handle.net/10347/18525
Título: | Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasis
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Autor/a: | Varela Calviño, Rubén
Cordero Santamaría, Óscar Javier
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Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Bioquímica e Bioloxía Molecular
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Palabras chave: | Colorectal cancer | Metastasis | Stem cells | Immune surveillance | Dendritic cells | Prognosis | Flow cytometry | Lymphocytes | Regulatory cells | |
Data: | 2015
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Editor: | Baishideng Publishing
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Cita bibliográfica: | Varela-Calviño R, Cordero OJ. Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasis. World J Immunol 2015; 5(2): 68-77 Available from: URL: http://www.wjgnet.com/2219-2824/full/ v5/i2/68.htm DOI: http://dx.doi.org/10.5411/wji.v5.i2.68
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Resumo: | An important percentage of colorectal cancer (CRC) patients will develop metastasis, mainly in the liver, even after a successful curative resection. This leads to a very high mortality rate if metastasis is not detected early on. Disseminated cancer cells develop from metastatic stem cells (MetSCs). Recent knowledge has accumulated about these cells particularly in CRC, so they may now be tracked from the removed primary tumour. This approach could be especially important in prognosis of metastasis because it is becoming clear that metastasis does not particularly rely on testable driver mutations. Among the many traits supporting an epigenetic amplification of cell survival and self-renewal mechanisms of MetSCs, the role of many immune cell populations present in tumour tissues is becoming clear. The amount of tumour-infiltrating lymphocytes (T, B and natural killer cells), dendritic cells and some regulatory populations have already shown prognostic value or to be correlated with disease-free survival time, mainly in immunohistochemistry studies of unique cell populations. Parallel analyses of these immune cell populations together with MetSCs in the primary tumour of patients, with later follow-up data of the patients, will define the usefulness of specific combinations of both immune and MetSCs cell populations. It is expected that these combinations, together to different biomarkers in the form of an immune score, may predict future tumour recurrences, metastases and/or mortality in CRC. It will also support the future design of improved immunotherapeutic approaches against metastasis |
Versión do editor: | https://doi.org/10.5411/wji.v5.i2.68 |
URI: | http://hdl.handle.net/10347/18525
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DOI: | 10.5411/wji.v5.i2.68 |
E-ISSN: | 2219-2824
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Dereitos: | ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Atribución-NoComercial 4.0 Internacional
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