In vivo degeneration and the fate of inorganic nanoparticles
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|Title:||In vivo degeneration and the fate of inorganic nanoparticles
Pino, Pablo del
Stauber, Roland H.
Parak, Wolfgang J.
|Affiliation:||Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
Universidade de Santiago de Compostela. Departamento de Física da Materia Condensada
|Date of Issue:||2016
|Publisher:||Royal Society of Chemistry
|Citation:||Chem. Soc. Rev., 2016,45, 2440-2457
|Abstract:||What happens to inorganic nanoparticles (NPs), such as plasmonic gold or silver, superparamagnetic iron oxide, or fluorescent quantum dot NPs after they have been administrated to a living being? This review discusses the integrity, biodistribution, and fate of NPs after in vivo administration. The hybrid nature of the NPs is described, conceptually divided into the inorganic core, the engineered surface coating comprising of the ligand shell and optionally also bio-conjugates, and the corona of adsorbed biological molecules. Empirical evidence shows that all of these three compounds may degrade individually in vivo and can drastically modify the life cycle and biodistribution of the whole heterostructure. Thus, the NPs may be decomposed into different parts, whose biodistribution and fate would need to be analyzed individually. Multiple labeling and quantification strategies for such a purpose will be discussed. All reviewed data indicate that NPs in vivo should no longer be considered as homogeneous entities, but should be seen as inorganic/organic/biological nanohybrids with complex and intricately linked distribution and degradation pathways|
|Rights:||Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence