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dc.contributor.authorFeliu, Neus
dc.contributor.authorDocter, Dominic
dc.contributor.authorHeine, Markus
dc.contributor.authorPino, Pablo del
dc.contributor.authorAshraf, Sumaira
dc.contributor.authorKolosnjaj-Tabi, Jelena
dc.contributor.authorMacchiarini, Paolo
dc.contributor.authorNielsen, Peter
dc.contributor.authorAlloyeau, Damien
dc.contributor.authorGazeau, Florence
dc.contributor.authorStauber, Roland H.
dc.contributor.authorParak, Wolfgang J.
dc.identifier.citationChem. Soc. Rev., 2016,45, 2440-2457
dc.description.abstractWhat happens to inorganic nanoparticles (NPs), such as plasmonic gold or silver, superparamagnetic iron oxide, or fluorescent quantum dot NPs after they have been administrated to a living being? This review discusses the integrity, biodistribution, and fate of NPs after in vivo administration. The hybrid nature of the NPs is described, conceptually divided into the inorganic core, the engineered surface coating comprising of the ligand shell and optionally also bio-conjugates, and the corona of adsorbed biological molecules. Empirical evidence shows that all of these three compounds may degrade individually in vivo and can drastically modify the life cycle and biodistribution of the whole heterostructure. Thus, the NPs may be decomposed into different parts, whose biodistribution and fate would need to be analyzed individually. Multiple labeling and quantification strategies for such a purpose will be discussed. All reviewed data indicate that NPs in vivo should no longer be considered as homogeneous entities, but should be seen as inorganic/organic/biological nanohybrids with complex and intricately linked distribution and degradation pathways
dc.description.sponsorshipThis work was partly funded by the European Commission (grant FutureNanoNeeds to WJP), the MINECO (MAT2013-48169-R, NanoFATE, to WJP and PdP), BMBF-MRCyte/NanoBEL, Zeiss-ChemBioMed, Stiftung Rheinland-Pfalz (NanoScreen), Peter und Traudl Engelhorn foundation, BIOMATICS (grants to RS, DD), DFG SPP1313 (grants to RS, PN, WJP), the CNRS (Centre National de la Recherche Scientifique, Defi Nano program), the ANR (Agence Nationale de la Recherche) and CGI (Commissariat à l'Investissement d'Avenir) through the LabEx SEAM (Science and Engineering for Advanced Materials and devices; ANR 11 LABX 086, ANR 11 IDEX 05 02) (grants to DA and FG). SA acknowledges the Alexander von Humboldt Foundation for a PostDoc fellowship and NF the Lars Hierta Memorial Foundation
dc.publisherRoyal Society of Chemistry
dc.rightsOpen Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence
dc.titleIn vivo degeneration and the fate of inorganic nanoparticles
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Física da Materia Condensada

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Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence
Except where otherwise noted, this item's license is described as  Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence

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