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http://hdl.handle.net/10347/19761
Título: | Nanoparticles engineered to bind cellular motors for efficient delivery
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Autor/a: | Dalmau-Mena, Inmaculada
Pino, Pablo del
Pelaz García, Beatriz
Cuesta-Geijo, Miguel Ángel
Galindo, Inmaculada
Moros, María
Martínez de la Fuente, Jesús
Alonso, Covadonga
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Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Física de Partículas
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Palabras chave: | Nanoparticles | Biomimetic synthetic peptides | Drug delivery | Microtubule motors | Dynein | |
Data: | 2018
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Editor: | BioMed Central
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Cita bibliográfica: | Dalmau-Mena, I., del Pino, P., Pelaz, B., Cuesta-Geijo, M., Galindo, I., & Moros, M. et al. (2018). Nanoparticles engineered to bind cellular motors for efficient delivery. Journal Of Nanobiotechnology, 16(1). doi: 10.1186/s12951-018-0354-1
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Resumo: | Background
Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as cell accumulation and active intra- and inter-cellular motion through cell-to-cell contacts and projections to distant cells. On the basis of these properties dynein-binding peptides could be used to functionalize nanoparticles for drug delivery applications.
Results
Here, we show that gold nanoparticles modified with dynein-binding delivery sequences become mobile, powered by molecular motor proteins. Modified nanoparticles showed dynamic properties, such as travelling the cytosol, crossing intracellular barriers and shuttling the nuclear membrane. Furthermore, nanoparticles were transported from one cell to another through cell-to-cell contacts and quickly spread to distant cells through cell projections.
Conclusions
The capacity of these motor-bound nanoparticles to spread to many cells and increasing cellular retention, thus avoiding losses and allowing lower dosage, could make them candidate carriers for drug delivery |
Versión do editor: | https://doi.org/10.1186/s12951-018-0354-1 |
URI: | http://hdl.handle.net/10347/19761
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DOI: | 10.1186/s12951-018-0354-1 |
ISSN: | 1477-3155
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Dereitos: | © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated Atribución 4.0 Internacional
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