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dc.contributor.authorDalmau-Mena, Inmaculada
dc.contributor.authorPino, Pablo del
dc.contributor.authorPelaz García, Beatriz
dc.contributor.authorCuesta-Geijo, Miguel Ángel
dc.contributor.authorGalindo, Inmaculada
dc.contributor.authorMoros, María
dc.contributor.authorMartínez de la Fuente, Jesús
dc.contributor.authorAlonso, Covadonga
dc.date.accessioned2019-09-11T11:09:29Z
dc.date.available2019-09-11T11:09:29Z
dc.date.issued2018
dc.identifier.citationDalmau-Mena, I., del Pino, P., Pelaz, B., Cuesta-Geijo, M., Galindo, I., & Moros, M. et al. (2018). Nanoparticles engineered to bind cellular motors for efficient delivery. Journal Of Nanobiotechnology, 16(1). doi: 10.1186/s12951-018-0354-1
dc.identifier.issn1477-3155
dc.identifier.urihttp://hdl.handle.net/10347/19761
dc.description.abstractBackground Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as cell accumulation and active intra- and inter-cellular motion through cell-to-cell contacts and projections to distant cells. On the basis of these properties dynein-binding peptides could be used to functionalize nanoparticles for drug delivery applications. Results Here, we show that gold nanoparticles modified with dynein-binding delivery sequences become mobile, powered by molecular motor proteins. Modified nanoparticles showed dynamic properties, such as travelling the cytosol, crossing intracellular barriers and shuttling the nuclear membrane. Furthermore, nanoparticles were transported from one cell to another through cell-to-cell contacts and quickly spread to distant cells through cell projections. Conclusions The capacity of these motor-bound nanoparticles to spread to many cells and increasing cellular retention, thus avoiding losses and allowing lower dosage, could make them candidate carriers for drug delivery
dc.description.sponsorshipThe present work was supported by grants from the Spanish Ministry of Economy, Industry and Competiveness AGL2012-34533, AGL2015-69598-R, SAF2014-54763-C2-2-R, Fondo Social de la DGA (grupos DGA), ERC-Starting Grant 239931-NANOPUZZLE and COST Action CA15138 Transautophagy. PdP and BP thanks financial support from the Consellería de Cultura, Educación e Ordenación Universitaria (Centro singular de investigación de Galicia accreditation 2016–2019, ED431G/09), and the European Regional Development Fund (ERDF)
dc.language.isoeng
dc.publisherBioMed Central
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/239931
dc.rights© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNanoparticles
dc.subjectBiomimetic synthetic peptides
dc.subjectDrug delivery
dc.subjectMicrotubule motors
dc.subjectDynein
dc.titleNanoparticles engineered to bind cellular motors for efficient delivery
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1186/s12951-018-0354-1
dc.relation.publisherversionhttps://doi.org/10.1186/s12951-018-0354-1
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Física de Partículas
dc.description.peerreviewedSI


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© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
Except where otherwise noted, this item's license is described as  © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated





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