Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring
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Título: | Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring |
Autor/a: | Eduardo Canosa, Silvina Laura Marco, María Sigüeiro Ponte, Rita Mouriño Mosquera, Antonio |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Palabras chave: | D-ring modified vitamin D analogs | Aryl-Cr(CO)3 complexes | Cancer | Sigmatropic rearrangements | Synthesis | |
Data: | 2018 |
Editor: | Academia Brasileira de Ciências |
Cita bibliográfica: | EDUARDO-CANOSA, SILVINA, SIGÜEIRO, MARÍA MARCO, RITA, & MOURIÑO, ANTONIO. (2018). Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring. Anais da Academia Brasileira de Ciências, 90(1, Suppl. 2), 1035-1042. https://dx.doi.org/10.1590/0001-3765201820170701 |
Resumo: | Herein, we describe our studies on the synthesis of 1α,25-dihydroxyvitamin D3 analogs possessing a benzene ring replacing the natural 5-membered D-ring by the Wittig-Horner and dienyne approaches. A key feature is the synthesis of a Cr(CO)3-complexed previtamin D derivative that enables the construction of vitamin D analogs with aromatic D-ring through a thermal [1,7]-H sigmatropic shift. This study establishes the basis for the design of new vitamin D analogs containing aromatic D-ring, complexed or uncomplexed to Cr(CO)3 type moieties for specific molecular recognition and drug research and development |
Versión do editor: | http://dx.doi.org/10.1590/0001-3765201820170701 |
URI: | http://hdl.handle.net/10347/19959 |
DOI: | 10.1590/0001-3765201820170701 |
ISSN: | 0001-3765 |
E-ISSN: | 1678-2690 |
Dereitos: | This is an open-access article distributed under the terms of the Creative Commons Attribution License |
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