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dc.contributor.authorEduardo Canosa, Silvina Laura
dc.contributor.authorMarco, María
dc.contributor.authorSigüeiro Ponte, Rita
dc.contributor.authorMouriño Mosquera, Antonio
dc.date.accessioned2019-10-26T11:38:10Z
dc.date.available2019-10-26T11:38:10Z
dc.date.issued2018
dc.identifier.citationEDUARDO-CANOSA, SILVINA, SIGÜEIRO, MARÍA MARCO, RITA, & MOURIÑO, ANTONIO. (2018). Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring. Anais da Academia Brasileira de Ciências, 90(1, Suppl. 2), 1035-1042. https://dx.doi.org/10.1590/0001-3765201820170701
dc.identifier.issn0001-3765
dc.identifier.urihttp://hdl.handle.net/10347/19959
dc.description.abstractHerein, we describe our studies on the synthesis of 1α,25-dihydroxyvitamin D3 analogs possessing a benzene ring replacing the natural 5-membered D-ring by the Wittig-Horner and dienyne approaches. A key feature is the synthesis of a Cr(CO)3-complexed previtamin D derivative that enables the construction of vitamin D analogs with aromatic D-ring through a thermal [1,7]-H sigmatropic shift. This study establishes the basis for the design of new vitamin D analogs containing aromatic D-ring, complexed or uncomplexed to Cr(CO)3 type moieties for specific molecular recognition and drug research and development
dc.description.sponsorshipWe thank Xunta de Galicia (project GPC2014/001) and for financial support. Silvina Eduardo thanks the Spanish MEC for a fellowship. Rita Sigüeiro thanks Xunta de Galicia for a post-doctoral fellowship (Axudas posdoutorais, plan I2C, mod B)
dc.language.isoeng
dc.publisherAcademia Brasileira de Ciências
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectD-ring modified vitamin D analogs
dc.subjectAryl-Cr(CO)3 complexes
dc.subjectCancer
dc.subjectSigmatropic rearrangements
dc.subjectSynthesis
dc.titleStudies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1590/0001-3765201820170701
dc.relation.publisherversionhttp://dx.doi.org/10.1590/0001-3765201820170701
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.e-issn1678-2690
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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This is an open-access article distributed under the terms of the Creative Commons Attribution License
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