Show simple item record

dc.contributor.advisorCastillo Sánchez José Antonio
dc.contributor.advisorSobrino Moreiras, Tomás
dc.contributor.advisorCampos Pérez, Francisco
dc.contributor.authorFernández Susavila, Héctor
dc.date.accessioned2019-12-30T12:06:08Z
dc.date.available2019-12-30T12:06:08Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/10347/20530
dc.description.abstractStroke is the main cause of mortality and morbidity in developed countries. A relevant percentage of strokes is due to several cerebrovascular pathologies with genetic background. While the study of these diseases in animal models is proving inefficient, with the development of the cellular reprogramming technology in 2006, a new approach appeared to overcome the existing barriers found in these models. Thanks to the cellular reprogramming technology, the current thesis supposes the first time that an in vitro cellular model with the patient's own cells is achieved for the study of one of these cerebrovascular pathologies, CADASIL, focusing on the abnormal behavior of the mutated protein NOTCH3.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHuman induced pluripotent stem cells
dc.subjectCADASIL
dc.subjectNOTCH3
dc.subject.classificationMaterias::Investigación::24 Ciencias de la vida::2407 Biología celular::240701 Cultivo celular
dc.subject.classificationMaterias::Investigación::32 Ciencias médicas::3207 Patología::320711 Neuropatología
dc.titleHuman iPSCs use as preclinical model for drug study in cerebrovascular diseases
dc.typeinfo:eu-repo/semantics/doctoralThesis
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)
dc.contributor.affiliationUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde
dc.contributor.affiliationUniversidade de Santiago de Compostela. Programa de Doutoramento en Medicina Molecular


Files in this item

application/pdf
Name: rep_1944.pdf
Size: 53.15 Mb
Format: PDF


Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as  Attribution-NonCommercial-NoDerivatives 4.0 Internacional





Harvesters:Useful links:
Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback