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dc.contributor.authorCarrillo Carrión, Carolina
dc.contributor.authorMartínez González, Raquel
dc.contributor.authorNavarro Poupard, María Fernanda
dc.contributor.authorPelaz García, Beatriz
dc.contributor.authorPolo Tobajas, Ester
dc.contributor.authorArenas-Vivo, Ana
dc.contributor.authorOlgiati, Alessandro
dc.contributor.authorTaboada Antelo, Pablo
dc.contributor.authorSoliman, Mahmoud G.
dc.contributor.authorCatalán, Úrsula
dc.contributor.authorFernández-Castillejo, Sara
dc.contributor.authorSolà, Rosa
dc.contributor.authorParak, Wolfgang J.
dc.contributor.authorHorcajada, Patricia
dc.contributor.authorAlvarez-Puebla, Ramon A.
dc.contributor.authorPino, Pablo del
dc.date.accessioned2020-01-29T08:40:08Z
dc.date.available2020-03-21T02:00:10Z
dc.date.issued2019-05-20
dc.identifier.citationC. Carrillo-Carrión, R. Martínez, M. F. Navarro Poupard, B. Pelaz, E. Polo, A. Arenas-Vivo, A. Olgiati, P. Taboada, M. G. Soliman, Ú. Catalán, S. Fernández-Castillejo, R. Solà, W. J. Parak, P. Horcajada, R. A. Alvarez-Puebla, P. del Pino, Angew. Chem. Int. Ed. 2019, 58, 7078
dc.identifier.issn1433-7851
dc.identifier.urihttp://hdl.handle.net/10347/20621
dc.descriptionThis is the peer reviewed version of the following article: C. Carrillo-Carrión, R. Martínez, M. F. Navarro Poupard, B. Pelaz, E. Polo, A. Arenas-Vivo, A. Olgiati, P. Taboada, M. G. Soliman, Ú. Catalán, S. Fernández-Castillejo, R. Solà, W. J. Parak, P. Horcajada, R. A. Alvarez-Puebla, P. del Pino, Angew. Chem. Int. Ed. 2019, 58, 7078, which has been published in final form at https:// doi.org/10.1002/anie.201902817. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
dc.description.abstractA plasmonic core–shell gold nanostar/zeolitic‐imidazolate‐framework‐8 (ZIF‐8) nanocomposite was developed for the thermoplasmonic‐driven release of encapsulated active molecules inside living cells. The nanocomposites were loaded, as a proof of concept, with bisbenzimide molecules as functional cargo and wrapped with an amphiphilic polymer that prevents ZIF‐8 degradation and bisbenzimide leaking in aqueous media or inside living cells. The demonstrated molecule‐release mechanism relies on the use of near‐IR light coupled to the plasmonic absorption of the core gold nanostars, which creates local temperature gradients and thus, bisbenzimide thermodiffusion. Confocal microscopy and surface‐enhanced Raman spectroscopy (SERS) were used to demonstrate bisbenzimide loading/leaking and near‐IR‐triggered cargo release inside cells, thereby leading to DNA staining
dc.description.sponsorshipThis work has received financial support from the MINECO‐Spain (MAT2016‐80266‐R, MAT2015‐74381‐JIN, CTQ2017‐88648R, ENE2016‐79608‐C2‐1‐R, CTQ2017‐89588‐R, RYC‐2014‐15039, RYC‐2014‐16962), the Xunta de Galicia, Centro singular de investigación de Galicia accreditation 2016–2019 (ED431G/09), the Agrupación Estratégica de Materiales Action (ED431E 2018/08), the Generalitat de Cataluña (2017SGR522, 2017SGR883, SLT002/16/00239), the URV (2017PFR‐URV‐B2‐02), the German Research Society (DFG PA 794‐21‐1), and the European Union (European Regional Development Fund—ERDF, H2020‐MSCA‐IF‐2016, project 749667). M.F.N.P acknowledges the CONACYT PhD fellowship program
dc.language.isoeng
dc.publisherWiley
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/749667
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2016‐80266‐R/ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015‐74381‐JIN/ES/CAPSULAS MAGNETICAS Y PLASMONICAS INTELIGENTES PARA EL TRATAMIENTO BASADO EN EL USO DE LNA-ANTIMIR DEL CANCER DE MAMA
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017‐88648R/ES/MATERIALES OPTICOS FUNCIONALES PARA LA MONITORIZACION Y TRATAMIENTO DE INFECCIONES EN PROTESIS E IMPLANTES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/ENE2016‐79608‐C2‐1‐R/ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017‐89588‐R/ES/NANOCAPSULAS BIOMIMETICAS PARA LA ADMINISTRACION DIRIGIDA DE NANOMEDICINAS
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC‐2014‐15039/ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC‐2014‐16962/ES
dc.rights© 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving
dc.subjectDrug release
dc.subjectMetal-organic frameworks
dc.subjectNanocomposites
dc.subjectThermoplasmonics
dc.subjectZIF-8
dc.titleAqueous Stable Gold Nanostar/ZIF‐8 Nanocomposites for Light‐Triggered Release of Active Cargo Inside Living Cells
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1002/anie.201902817
dc.relation.publisherversionhttps://doi.org/10.1002/anie.201902817
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.e-issn1521-3773
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Física de Partículas
dc.description.peerreviewedSI


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