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dc.contributor.authorCarrillo Carrión, Carolina
dc.date.accessioned2020-01-29T11:47:27Z
dc.date.available2020-11-16T02:00:07Z
dc.date.issued2020-01
dc.identifier.citationCarrillo-Carrión, C. Anal Bioanal Chem (2020) 412: 37. https://doi.org/10.1007/s00216-019-02217-y
dc.identifier.issn1618-2642
dc.identifier.urihttp://hdl.handle.net/10347/20625
dc.descriptionThis is a post-peer-review, pre-copyedit version of an article published in Analytical and Bioanalytical Chemistry. The final authenticated version is available online at: https://doi.org/10.1007/s00216-019-02217-y
dc.description.abstractMetal–organic frameworks (MOFs) have emerged as one of the most fascinating libraries of porous materials with a huge potential in very diverse application areas. In particular, the bioanalytical and biomedical fields have evolved tremendously due to the emergence of these hybrid inorganic–organic MOF-based materials. This is because these materials possess a series of key properties essential for bioapplications, such as minimal toxicity to living cells, intrinsic biodegradability, and possibility of synthesizing with nanoscale sizes. Additional properties of MOFs such as ultra-large surface-to-volume ratios, tunable pore size, high drug loading capacity, tunable structure and chemical composition, and potential for multiple postsynthetic modification make them ideal candidates for drug delivery. This review highlights recent research progress on MOF-based drug delivery systems (DDS), pointing out the evolution of these systems toward the development of theranostic nanoplatforms. Rather than a comprehensive review, representative recent examples are selected to illustrate such an evolution, and a critical discussion of the advantages and limitations of the different DDS types is given. Finally, the remaining challenges and future opportunities in this field are presented, highlighting that overcoming the current issues will pave the way toward the elusive dream of “personalized medicine.”
dc.description.sponsorshipC.C.C. thanks the financial support from the European Union under the H2020-MSCA-IF-2016 program (MSCA-IF-EF-ST Grant Agreement No. 749667)
dc.language.isoeng
dc.publisherSpringer
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/749667
dc.rights© Springer-Verlag GmbH Germany, part of Springer Nature 2019
dc.subjectMetal–organic framework
dc.subjectNanoscale
dc.subjectDrug delivery
dc.subjectTheranostics
dc.subjectStimuli-responsive
dc.titleNanoscale metal–organic frameworks as key players in the context of drug delivery: evolution toward theranostic platforms
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1007/s00216-019-02217-y
dc.relation.publisherversionhttps://doi.org/10.1007/s00216-019-02217-y
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.e-issn1618-2650
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Física de Partículas
dc.description.peerreviewedSI


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