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dc.contributor.authorMéndez Ardoy, Alejandro
dc.contributor.authorReina Martín, Jose Juan
dc.contributor.authorMontenegro García, Javier
dc.date.accessioned2020-02-05T11:52:16Z
dc.date.issued2020
dc.identifier.citationMéndez-Ardoy, A., Reina, J..J. and Montenegro, J. (2020), Synthesis and Supramolecular Functional Assemblies of Ratiometric pH Probes. Chem. Eur. J.. doi:10.1002/chem.201904834
dc.identifier.issn0947-6539
dc.identifier.urihttp://hdl.handle.net/10347/20678
dc.description.abstractTracking the pH with spatiotemporal resolution is a critical challenge for synthetic chemistry, chemical biology and beyond. Over the last decade different small probes and supramolecular systems have emerged for in celluloor in vivo pH tracking. However, pH reporting still presents critical limitations such as background reduction, sensor improved stability, cell targeting, endosomal escape, near and far infrared ratiometric pH tracking, adaptation to the new imaging techniques (i.e. super‐resolution), etc. These challenges will demand the combined efforts of synthetic and supramolecular chemistry working together to develop a next generation of smart materials that will resolve the current limitations. In this review we describe the recent advances in the synthesis of small fluorescent probes together with new supramolecular functional systems employed for pH tracking with emphasis in ratiometric probes. The combination of organic synthesis and stimuli‐responsive supramolecular functional materials will be essential to solve future challenges of pH tracking such as the improved signal to noise ratio, on target activation and microenvironment reporting
dc.description.sponsorshipThis work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [SAF2017-89890-R], the Xunta de Galicia (ED431C 2017/25, 2016-AD031 and Centro Singular de Investigación de Galicia accreditation 2016–2019, ED431G/09), the ISCIII (RD16/0008/003), and the European Union (European Regional Development Fund –ERDF). A.M. received a Marie Curie fellowship (GLYCONANOPEP-750248). J.M. received a Ramón y Cajal (RYC-2013-13784), an ERC Starting Investigator Grant (DYNAP-677786) and a Young Investigator Grant from the Human Frontier Science Research Program (RGY0066/2017)
dc.language.isoeng
dc.publisherWiley
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/750248
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/677786
dc.rights© 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
dc.subjectFluorescent probes
dc.subjectSupramolecular Chemistry
dc.subjectOrganic synthesis
dc.subjectRatiometric probes
dc.titleSynthesis and Supramolecular Functional Assemblies of Ratiometric pH Probes
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1002/chem.201904834
dc.relation.publisherversionhttps://doi.org/10.1002/chem.201904834
dc.description.embargo2021-01-15
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.e-issn1521-3765
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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