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dc.contributor.authorInsua López, Ignacio
dc.contributor.authorMontenegro García, Javier
dc.date.accessioned2020-02-05T11:52:38Z
dc.date.available2021-01-09T02:00:09Z
dc.date.issued2020
dc.identifier.citationJ. Am. Chem. Soc. 2020, 142, 1, 300-307
dc.identifier.issn0002-7863
dc.identifier.urihttp://hdl.handle.net/10347/20679
dc.description.abstractDespite recent developments in two-dimensional self-assembly, most supramolecular 2D materials are assembled by tedious methodologies, with complex surface chemistry and small sizes. We here report d/l-alternating cyclic peptides that undergo one-dimensional self-assembly into amphiphilic nanotubes, which subsequently arrange as tubular bilayers to form giant nanosheets in the mesoscale. Reversible transitions between the assembled, dispersed, and aggregated states of these nanosheets can be triggered by external stimuli. The characteristic flexibility, defined chemical topology, and length scale of these nanosheets set a clear distinction between this new supramolecular architecture and previously reported 2D nanostructures. The sequential 1D-to-2D self-assembly of peptides described here provides a conceptually new approach to achieve two-dimensional materials with hierarchical organization. These giant nanosheets represent one of the largest 2D supramolecular materials ever made, with potential application as long-range molecular transporters, responsive surfaces, and (bio)sensors
dc.description.sponsorshipThis work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [SAF2017-89890-R], the Xunta de Galicia (ED431C 2017/25, 2016-AD031 and Centro Singular de Investigación de Galicia accreditation 2016-2019, ED431G/09), the ISCIII (RD16/0008/003), and the European Union (European Regional Development Fund, ERDF). I.I. thanks the European Commission for a Marie Curie fellowship (MSCA-IF-2018-843332) and the Spanish AEI for a Juan de la Cierva—Formación Fellowship (FJCI-2017-31795). J.M. received a Ramón y Cajal (RYC-2013-13784), an ERC Starting Investigator Grant (DYNAP-677786), and a Young Investigator Grant from the HFSP (RGY0066/2017). We thank Dr. Eugenio Solla, Prof. Juan Granja, Dr. Julian Bergueiro, Dr. Andreas Vargas Jentzsch, and Dr. Mark J. van Raaij for helpful discussions. We also thank Dr. Bergueiro for Figure 1 and Dr. Vargas Jentzsch for assistance with DFT calculations
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/677786
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/843332
dc.rightsCopyright © 2019 American Chemical Society
dc.subjectSelf organization
dc.subjectPeptides and proteins
dc.subjectNanotubes
dc.subjectMonomers
dc.subjectTwo dimensional materials
dc.title1D to 2D Self Assembly of Cyclic Peptides
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1021/jacs.9b10582
dc.relation.publisherversionhttps://doi.org/10.1021/jacs.9b10582
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.e-issn1520-5126
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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